Reactome | klhl21 [cytosol]

klhl21 [cytosol]

Stable Identifier

R-DRE-976026

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

KLHL21, Q6NYM1

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Class I MHC mediated antigen processing & presentation (Danio rerio)
    - Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
      - Interaction of E3 with substrate and E2-Ub complex (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
      - Polyubiquitination of substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
      - Release of E3 from polyubiquitinated substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
      - Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Neddylation (Danio rerio)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Danio rerio)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Danio rerio)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        klhl21 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6NYM1

Gene Names

klhl21

Reference Genes

BioGPS Gene:404613 klhl21

ENSEMBL:ENSDARG00000039255

KEGG:dre:404613 klhl21

Monarch:404613 klhl21

NCBI Gene:404613 klhl21

UCSC:Q6NYM1 klhl21

Reference Transcript

Other Identifiers

13134063

13279298

404613

A_15_P108781

A_15_P183581

A_15_P584177

CUST_16348_PI428451953

CUST_16349_PI428451953

CUST_16350_PI428451953

CUST_5769_PI423952288

CUST_5770_PI423952288

CUST_5771_PI423952288

CUST_5772_PI423952288

CUST_5773_PI423952288

CUST_5774_PI423952288

CUST_5775_PI423952288

CUST_5776_PI423952288

CUST_8100_PI428451958

DRER07493

DRER35449

DRER36628

DRER39195

ENSDART00000057357

ENSDART00000057357_1

ENSDART00000057357_2

GO:0005515

GO:0016567

GT_Spec_NM_207081.1_424785

GT_Xhyb_XM_005162159.1_413535

GT_Xhyb_XM_005162160.1_413545

GT_Xhyb_XM_005162161.1_20011

MADDr01008909

NM_207081

OTTDART00000028079

OTTDART00000028080

Participates

as a member of

BTB proteins [cytosol] (Danio rerio)

Inferred From

KLHL21 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005162217.1, XP_073794322.1, XP_021325447.1, NP_001307336.1

ENSEMBL

ENSDARP00000115156, ENSDART00000140335, ENSDARG00000039255, ENSDART00000137486, ENSDARP00000121765

ZFIN

ZDB-GENE-040426-2627

PRO

Q6NYM1

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