Reactome | Klhl21 [cytosol]

Klhl21 [cytosol]

Stable Identifier

R-RNO-976026

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

KLHL21, D4A2K4

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
      - Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
      - Polyubiquitination of substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
      - Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
      - Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl21 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D4A2K4

Gene Names

Klhl21

Reference Genes

BioGPS Gene:313743 Klhl21

ENSEMBL:ENSRNOG00000003334

ENSEMBL:ENSRNOG00000003334.6 Klhl21

ENSEMBL:ENSRNOG00055015527

ENSEMBL:ENSRNOG00060003558

ENSEMBL:ENSRNOG00065009694

KEGG Gene (Rattus norvegicus):313743 Klhl21

Monarch:313743 Klhl21

NCBI Gene:313743 Klhl21

UCSC:D4A2K4 Klhl21

Reference Transcript

RefSeq:NM_001107996.1 Klhl21

Other Identifiers

10874240

1371995_at

17804503

313743

5664846

5823784

6152517

6164797

6246538

6253769

6508704

6555958

6712920

6714190

6745829

A_43_P20207

A_64_P041802

A_64_P041807

GE1174539

GE1184226

GO:0000910

GO:0003824

GO:0004842

GO:0005515

GO:0005827

GO:0005856

GO:0016567

GO:0016740

GO:0031463

GO:0032465

GO:0035853

GO:0036211

GO:0043226

GO:0097602

GO:0140096

ILMN_1650312

PH_rn_0007573

rc_AI102706_at

Participates

as a member of

BTB proteins [cytosol] (Rattus norvegicus)

Inferred From

KLHL21 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001101466.1

Ensembl

ENSRNOG00000003334, ENSRNOT00000004508, ENSRNOP00000004508

PRO

D4A2K4

RGD

1305863

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