Reactome | KLHL21 [cytosol]

KLHL21 [cytosol]

Stable Identifier

R-GGA-976026

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

KLHL21, A0A8V0ZFG4

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Adaptive Immune System (Gallus gallus)
  - Class I MHC mediated antigen processing & presentation (Gallus gallus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
      - Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)
      - Polyubiquitination of substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)
      - Release of E3 from polyubiquitinated substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)
      - Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)

Metabolism of proteins (Gallus gallus)

- Post-translational protein modification (Gallus gallus)
  - Neddylation (Gallus gallus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Gallus gallus)
        
        CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)
      - CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Gallus gallus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL21 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0ZFG4

Gene Names

KLHL21

Reference Genes

BioGPS Gene:428175 KLHL21

ENSEMBL:ENSGALG00010018941.1

Monarch:428175 KLHL21

NCBI Gene:428175 KLHL21

UCSC:A0A8V0ZFG4 KLHL21

Reference Transcript

Other Identifiers

428175

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005819

GO:0005827

GO:0005856

GO:0016567

GO:0016740

GO:0030163

GO:0031463

GO:0032465

GO:0035853

GO:0043161

GO:0043226

GO:0051301

GO:0060090

GO:0097602

GO:0140096

GO:1990756

GT_A_87_P012470

GT_A_87_P065296

GT_A_87_P232098

GT_Sp_Chicken_CN220390_2453

Gga.19078.1.S1_at

GgaAffx.403.1.S1_at

Participates

as a member of

BTB proteins [cytosol] (Gallus gallus)

Inferred From

KLHL21 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015152479.2, XP_040544843.1

ENSEMBL

ENSGALG00010018941, ENSGALP00010027316, ENSGALT00010045830

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