AcK-NFE2L2-dependent GSTA1 gene expression

Stable Identifier
R-HSA-9760128
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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AcK-NFE2L2-dependent GSTA1 gene expression
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Gluthathione-S-transferase contributes to the antioxidant response by catalyzing the conjugation of glutathione to a range of endogenous and exogenous compounds, including peroxides and other oxidizing agents (reviewed in Chatterjee et al, 2018; Baird and Yamamoto, 2020). GSTA1 expression is driven in part by the binding of a heterodimer of MAFK and acetylated NFE2L2 to the antioxidant response element (ARE) in the promoter (Itoh et al, 1997; Thimmulappa et al, 2002; Sun et al, 2009).
Literature References
PubMed ID Title Journal Year
12234984 Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Thimmulappa, RK, Mai, KH, Srisuma, S, Kensler, TW, Yamamoto, M, Biswal, S

Cancer Res 2002
9240432 An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Itoh, K, Chiba, T, Takahashi, S, Ishii, T, Igarashi, K, Katoh, Y, Oyake, T, Hayashi, N, Satoh, K, Hatayama, I, Yamamoto, M, Nabeshima, Y

Biochem Biophys Res Commun 1997
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Baird, L, Yamamoto, M

Mol Cell Biol 2020
29959055 The multifaceted role of glutathione S-transferases in cancer

Chatterjee, A, Gupta, S

Cancer Lett 2018
19273602 Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response

Sun, Z, Chin, YE, Zhang, DD

Mol Cell Biol 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
GSTA1 gene:p-AcK-NFE2L2:MAFK:CREBBP, EP300 [nucleoplasm] (Homo sapiens)
Active Unit
p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm]
MAFK [nucleoplasm]
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2021-12-14)
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