Gluthathione-S-transferase contributes to the antioxidant response by catalyzing the conjugation of glutathione to a range of endogenous and exogenous compounds, including peroxides and other oxidizing agents (reviewed in Chatterjee et al, 2018; Baird and Yamamoto, 2020). GSTA1 expression is driven in part by the binding of a heterodimer of MAFK and acetylated NFE2L2 to the antioxidant response element (ARE) in the promoter (Itoh et al, 1997; Thimmulappa et al, 2002; Sun et al, 2009).
Yamamoto, M, Srisuma, S, Mai, KH, Biswal, S, Thimmulappa, RK, Kensler, TW
Ishii, T, Hatayama, I, Nabeshima, Y, Yamamoto, M, Takahashi, S, Satoh, K, Oyake, T, Hayashi, N, Igarashi, K, Itoh, K, Chiba, T, Katoh, Y
Yamamoto, M, Baird, L
Chatterjee, A, Gupta, S
Sun, Z, Zhang, DD, Chin, YE
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