AcK-NFE2L2 binds the TXNRD1 promoter

Stable Identifier
R-HSA-9759332
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AcK-NFE2L2 binds the TXNRD1 promoter
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TXNRD1 expression is regulated downstream of the KEAP1-NFE2L2 pathway in response to oxidative and electrophilic stress (Kwak et al, 2003; Kim et al, 2001; Malhotra et al, 2010; reviewed in Baird and Yamamoto, 2020). NFE2L2 binds the antioxidant response element (ARE) as assessed by ChIP in mouse studies. Expression of TXNRD1 is significantly upregulated in the absence of KEAP1, marking it as an inducible NFE2L2 target gene (Malhotra et al, 2010). Binding and transcriptional activation by NFE2L2 at the TXNRD1 promoter is enhanced by CREBBP- or EP300-mediated acetylation of NFE2L2 at 18 residues in the N-terminal Neh1 domain (Sun et al, 2009).
Literature References
PubMed ID Title Journal Year
20460467 Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

Malhotra, D, Portales-Casamar, E, Singh, A, Srivastava, S, Arenillas, D, Happel, C, Shyr, C, Wakabayashi, N, Kensler, TW, Wasserman, WW, Biswal, S

Nucleic Acids Res 2010
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Baird, L, Yamamoto, M

Mol Cell Biol 2020
17234762 Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology

Kim, YJ, Ahn, JY, Liang, P, Ip, C, Zhang, Y, Park, YM

Cancer Res 2007
12506115 Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

Kwak, MK, Wakabayashi, N, Itoh, K, Motohashi, H, Yamamoto, M, Kensler, TW

J Biol Chem 2003
19273602 Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response

Sun, Z, Chin, YE, Zhang, DD

Mol Cell Biol 2009
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Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2021-12-02)
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