NFE2L2 binds the GSTA3 promoter

Stable Identifier
R-HSA-9759325
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NFE2L2 binds the GSTA3 promoter
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The gene for GSTA3 encodes glutathione-S-transferase A3, which catalyzes the addition of reduced glutathione onto a range of hydrophobic electrophiles, detoxifying them (reviewed in Baird and Yamamoto, 2020). GSTA3 expression is regulated by the KEAP1:NFE2L2 signaling pathway in response to oxidative and electrophilic stress (Itoh et al, 1997; McMahon et al, 2001). NFE2L2 binds to the antioxidant response element in the GSTA3 promoter to stimulate expression as assessed by ChIP, mRNA and protein levels (Itoh et al, 1997; McMahon et al, 2001; Malhotra et al, 2010).
Literature References
PubMed ID Title Journal Year
20460467 Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

Shyr, C, Srivastava, S, Wakabayashi, N, Wasserman, WW, Singh, A, Malhotra, D, Biswal, S, Happel, C, Portales-Casamar, E, Kensler, TW, Arenillas, D

Nucleic Acids Res 2010
11309284 The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

Cavin, C, Wolf, CR, Chanas, SA, McMahon, M, McLellan, LI, Henderson, CJ, Yamamoto, M, Hayes, JD, Itoh, K

Cancer Res 2001
9240432 An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Ishii, T, Hatayama, I, Nabeshima, Y, Yamamoto, M, Takahashi, S, Satoh, K, Oyake, T, Hayashi, N, Igarashi, K, Itoh, K, Chiba, T, Katoh, Y

Biochem Biophys Res Commun 1997
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
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Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2021-12-02)
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