Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Cobalamin (Cbl) metabolism
Stable Identifier
R-HSA-9759218
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Cobalamin (Cbl) metabolism (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
The reactions by which adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl) cofactors are synthesized and regenerated are annotated here (Banerjee et al. 2021).
Literature References
PubMed ID
Title
Journal
Year
33797888
Redox-Linked Coordination Chemistry Directs Vitamin B
12
Trafficking
Gouda, H
,
Pillay, S
,
Banerjee, R
Acc Chem Res
2021
Participants
Events
MMACHC dealkylates RCbl
(Homo sapiens)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin
(Homo sapiens)
MMACHC decyanates CNCbl
(Homo sapiens)
MMACHC:cob(II)alamin binds MMADHC
(Homo sapiens)
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR
(Homo sapiens)
MTRR reduces cob(II)alamin to meCbl
(Homo sapiens)
MTR transfers CH3 from MeCbl to HCYS
(Homo sapiens)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin
(Homo sapiens)
MMADHC targets transport of cytosolic cob(II)alamin to mitochondria
(Homo sapiens)
MMAB adenosylates cob(I)alamin
(Homo sapiens)
MMAA:MUT binds AdoCbl
(Homo sapiens)
Participates
as an event of
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Event Information
Go Biological Process
cobalamin metabolic process (0009235)
Orthologous Events
Cobalamin (Cbl) metabolism (Bos taurus)
Cobalamin (Cbl) metabolism (Caenorhabditis elegans)
Cobalamin (Cbl) metabolism (Canis familiaris)
Cobalamin (Cbl) metabolism (Danio rerio)
Cobalamin (Cbl) metabolism (Dictyostelium discoideum)
Cobalamin (Cbl) metabolism (Gallus gallus)
Cobalamin (Cbl) metabolism (Mus musculus)
Cobalamin (Cbl) metabolism (Rattus norvegicus)
Cobalamin (Cbl) metabolism (Sus scrofa)
Cobalamin (Cbl) metabolism (Xenopus tropicalis)
Authored
Jassal, B (2007-04-24)
Reviewed
Hill, DP (2022-02-14)
Created
D'Eustachio, P (2021-11-29)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text