cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR

Stable Identifier
R-HSA-3204318
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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In a sequence of events that is still not well understood, cob(II)alamin is transferred from its complex with MMACHC (Methylmalonic aciduria and homocystinuria type C protein) and MMADHC (Methylmalonic aciduria and homocystinuria type D protein) to the complex of MTRR (methionine synthase reductase) and methionine synthase (MTR) (Banerjee et al. 2021; Deme et al. 2012; Mah et al. 2013; Plesa et al. 2011; Wolthers & Scrutton 2007; Wolthers & Scrutton 2009) and the MMACHC:MMADHC complex dissociates.

Literature References
PubMed ID Title Journal Year
21071249 Interaction between MMACHC and MMADHC, two human proteins participating in intracellular vitamin B?? metabolism

Hancock, MA, Ng-Thow-Hing, C, Paquette, SG, Gibbs, BF, Rosenblatt, DS, Plesa, M, Kim, J, Coulton, JW, Gagnon, H

Mol. Genet. Metab. 2011
33797888 Redox-Linked Coordination Chemistry Directs Vitamin B12 Trafficking

Gouda, H, Pillay, S, Banerjee, R

Acc Chem Res 2021
17892308 Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry

Scrutton, NS, Wolthers, KR, Leys, D, Lou, X, Toogood, HS

Biochemistry 2007
23270877 Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B(12) metabolism

Deme, JC, Rosenblatt, DS, Mah, W, Shoubridge, EA, Fung, S, Watkins, D, Coulton, JW, Janer, A

Mol. Genet. Metab. 2013
19243433 Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase-methionine synthase reductase complex

Scrutton, NS, Wolthers, KR

FEBS J. 2009
22832074 Structural features of recombinant MMADHC isoforms and their interactions with MMACHC, proteins of mammalian vitamin B12 metabolism

Hancock, MA, Kim, JC, Deme, JC, Rosenblatt, DS, Plesa, M, Miousse, IR, Mah, W, Coulton, JW

Mol. Genet. Metab. 2012
17477549 Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation

Scrutton, NS, Wolthers, KR

Biochemistry 2007
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