Reactome | cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR

cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR

Stable Identifier

R-HSA-3204318

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR

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In a sequence of events that is still not well understood, cob(II)alamin is transferred from its complex with MMACHC (Methylmalonic aciduria and homocystinuria type C protein) and MMADHC (Methylmalonic aciduria and homocystinuria type D protein) to the complex of MTRR (methionine synthase reductase) and methionine synthase (MTR) (Banerjee et al. 2021; Deme et al. 2012; Mah et al. 2013; Plesa et al. 2011; Wolthers & Scrutton 2007; Wolthers & Scrutton 2009) and the MMACHC:MMADHC complex dissociates.

Literature References

PubMed ID	Title	Journal	Year
21071249	Interaction between MMACHC and MMADHC, two human proteins participating in intracellular vitamin B?? metabolism Hancock, MA, Ng-Thow-Hing, C, Paquette, SG, Gibbs, BF, Rosenblatt, DS, Plesa, M, Kim, J, Coulton, JW, Gagnon, H	Mol. Genet. Metab.	2011
33797888	Redox-Linked Coordination Chemistry Directs Vitamin B₁₂ Trafficking Gouda, H, Pillay, S, Banerjee, R	Acc Chem Res	2021
17892308	Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry Scrutton, NS, Wolthers, KR, Leys, D, Lou, X, Toogood, HS	Biochemistry	2007
23270877	Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B(12) metabolism Deme, JC, Rosenblatt, DS, Mah, W, Shoubridge, EA, Fung, S, Watkins, D, Coulton, JW, Janer, A	Mol. Genet. Metab.	2013
19243433	Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase-methionine synthase reductase complex Scrutton, NS, Wolthers, KR	FEBS J.	2009
22832074	Structural features of recombinant MMADHC isoforms and their interactions with MMACHC, proteins of mammalian vitamin B12 metabolism Hancock, MA, Kim, JC, Deme, JC, Rosenblatt, DS, Plesa, M, Miousse, IR, Mah, W, Coulton, JW	Mol. Genet. Metab.	2012
17477549	Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation Scrutton, NS, Wolthers, KR	Biochemistry	2007