Reactome | cob(II)alamin binds to MTRR:MTR

cob(II)alamin binds to MTRR:MTR

Stable Identifier

R-HSA-3204318

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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Methionine synthase reductase (MTRR) is involved in reducing cob(II)alamin (B_12r) to cob(I)alamin (B_12s), the cofactor form used by methionine synthase (MTR). MTRR requires 1 FMN and 1 FAD per subunit for activity (Wolthers et al. 2007). MTRR exists a stable complex with MTR, bound through their FMN-binding and C-terminal activation domains respectively (Wolthers & Scrutton 2007, Wolthers & Scrutton 2009).

Literature References

PubMed ID	Title	Journal	Year
19243433	Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase-methionine synthase reductase complex Wolthers, KR, Scrutton, NS	FEBS J.	2009
17892308	Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry Wolthers, KR, Lou, X, Toogood, HS, Leys, D, Scrutton, NS	Biochemistry	2007
17477549	Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation Wolthers, KR, Scrutton, NS	Biochemistry	2007