Reactome | MTR transfers CH3 from MeCbl to HCYS

MTR transfers CH3 from MeCbl to HCYS

Stable Identifier

R-HSA-174374

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Methionine is reformed

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase II - Conjugation of compounds (Homo sapiens)
    - Methylation (Homo sapiens)
      - MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)
- Metabolism of amino acids and derivatives (Homo sapiens)
  - Sulfur amino acid metabolism (Homo sapiens)
    - MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)
- Metabolism of vitamins and cofactors (Homo sapiens)
  - Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
    - Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
      - Cobalamin (Cbl) metabolism (Homo sapiens)
        
        MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)

General

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Methionine synthase (MTR) mediates the continuous shuttling of cobalamin (Cbl) between two forms, cob(I)alamin and MeCbl. In this half reaction, the methyl group from MeCbl is transferred to homocysteine (HYCS) to form methionine and regenerate cob(I)alamin (Hall et al. 2000; Leclerc et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
8968737	Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders Leclerc, D, Campeau, E, Goyette, P, Adjalla, CE, Christensen, B, Ross, M, Eydoux, P, Rosenblatt, DS, Rozen, R, Gravel, RA	Hum Mol Genet	1996
10978155	Interaction of flavodoxin with cobalamin-dependent methionine synthase Hall, DA, Jordan-Starck, TC, Loo, RO, Ludwig, ML, Matthews, RG	Biochemistry	2000