MTR transfers CH3 from MeCbl to HCYS

Stable Identifier
R-HSA-174374
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Methionine is reformed
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Methionine synthase (MTR) mediates the continuous shuttling of cobalamin (Cbl) between two forms, cob(I)alamin and MeCbl. In this half reaction, the methyl group from MeCbl is transferred to homocysteine (HYCS) to form methionine and regenerate cob(I)alamin (Hall et al. 2000; Leclerc et al. 1996).

Literature References
PubMed ID Title Journal Year
8968737 Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders

Ross, M, Adjalla, CE, Eydoux, P, Gravel, RA, Rosenblatt, DS, Christensen, B, Leclerc, D, Campeau, E, Rozen, R, Goyette, P

Hum Mol Genet 1996
10978155 Interaction of flavodoxin with cobalamin-dependent methionine synthase

Jordan-Starck, TC, Ludwig, ML, Loo, RO, Hall, DA, Matthews, RG

Biochemistry 2000
Participants
Participates
Catalyst Activity

methionine synthase activity of MTRR:MTR:MeCbl [cytosol]

Orthologous Events
Authored
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