NFE2L2 and MAFK bind the HMOX1 gene

Stable Identifier
R-HSA-9759137
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NFE2L2 and MAFK bind the HMOX1 gene
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The HMOX1 gene encodes heme oxygenase, which converts free heme into billiverden. HMOX1 activity is cytoprotective, as excess free heme promotes apoptosis (reviewed in Loboda et al, 2016; Waza et al, 2018). HMOX1 gene expression is regulated in part by the binding of heterodimers of NFE2L2 and small MAF proteins such as MAFK to the antioxidant response element in the promoter (Ishii et al, 2000; reviewed in Baird and Yamamoto, 2020).
Literature References
PubMed ID Title Journal Year
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Baird, L, Yamamoto, M

Mol Cell Biol 2020
10821856 Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

Ishii, T, Itoh, K, Takahashi, S, Sato, H, Yanagawa, T, Katoh, Y, Bannai, S, Yamamoto, M

J Biol Chem 2000
29693710 A review on heme oxygenase-1 induction: is it a necessary evil

Waza, AA, Hamid, Z, Ali, S, Bhat, SA, Bhat, MA

Inflamm Res 2018
27100828 Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

Loboda, A, Damulewicz, M, Pyza, E, Jozkowicz, A, Dulak, J

Cell Mol Life Sci 2016
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Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2021-11-29)
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