IMPDH tetramers dehydrogenate 6TIMP to 6TXMP

Stable Identifier
R-HSA-9748945
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
6TIMP--IMPDH-->6TXMP
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Inosine 5′-monophosphate dehydrogenase (IMPDH) is a key enzyme in the de novo synthesis of guanine nucleotides and is positioned at the branch point between adenine and guanine biosynthesis. It is also strategically positioned in the metabolic pathway of thiopurines. IMPDH is considered to be the rate-limiting enzyme in the metabolism of thiopurine drugs to 6-thioguanine nucleotides (6-TGNs) (Leyva et al. 1976). IMPDH dehydrogenates 6-thioinosine 5’-monophosphate (6TIMP) to 6-thioxanthosine 5'-monophosphate (6TXMP), an intermediate metabolite in the formation of 6-TGNs.

Literature References
PubMed ID Title Journal Year
942489 Effect of 6-mercaptopurine on inosinic acid dehydrogenase in cultured human fibroblasts

kelley, WN, Holmes, EW, Leyva, A

Biochem Pharmacol 1976
Participants
Participates
Event Information
Catalyst Activity

IMP dehydrogenase activity of IMPDH tetramers [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!