Triazenes produce DNA damage in the form of O6-methylguanine

Stable Identifier
R-HSA-9732692
Type
Reaction [omitted]
Species
Homo sapiens
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Monofunctional alkylating chemotherapeutic agents from the triazene family, dacarbazine (Souliotis et al. 1991), procarbazine (Souliotis et al. 1990), temozolomide (Taverna et al. 1992 - study done in mice) and streptozotocin (Bennett and Pegg 1981 - study done in rats), produce DNA damage in the form of O6-methylguanine (O6meG), which can be reversed by MGMT (6-O-methylguanine-DNA methyltransferase).

Literature References
PubMed ID Title Journal Year
2328502 Accumulation of O6-methylguanine in human blood leukocyte DNA during exposure to procarbazine and its relationships with dose and repair

Souliotis, VL, Kaila, S, Boussiotis, VA, Pangalis, GA, Kyrtopoulos, SA

Cancer Res 1990
1421437 Influence of O6-methylguanine on DNA damage and cytotoxicity of temozolomide in L1210 mouse leukemia sensitive and resistant to chloroethylnitrosoureas

Taverna, P, Catapano, CV, Citti, L, Bonfanti, M, D'Incalci, M

Anticancer Drugs 1992
1704822 In vivo formation and repair of O6-methylguanine in human leukocyte DNA after intravenous exposure to dacarbazine

Souliotis, VL, Boussiotis, VA, Pangalis, GA, Kyrtopoulos, SA

Carcinogenesis 1991
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