Temozolomide produces DNA damage in the form of O6-methylguanine in mouse dsDNA

Stable Identifier
R-MMU-9749883
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Temozolomide produces DNA damage in the form of O6-methylguanine in mouse dsDNA

Using mouse leukemic cell line as a model system, it was shown that temozolomide produces DNA damage in the form of O6-methylguanine (Taverna et al. 1992).

Literature References
PubMed ID Title Journal Year
1421437 Influence of O6-methylguanine on DNA damage and cytotoxicity of temozolomide in L1210 mouse leukemia sensitive and resistant to chloroethylnitrosoureas

Citti, L, Bonfanti, M, D'Incalci, M, Taverna, P, Catapano, CV

Anticancer Drugs 1992
Participants
Input
Output
Orthologous Events
Triazenes produce DNA damage in the form of O6-methylguanine (Homo sapiens)
Authored
Orlic-Milacic, M  (2021-05-28)
Reviewed
Kadambat Nair, S  (2021-07-28)
Created
Orlic-Milacic, M  (2021-08-06)
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