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dsDNA [nucleoplasm]
Stable Identifier
R-HSA-5649637
Type
Genes and Transcripts [GenomeEncodedEntity]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Double Strand DNA
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
DSB inducing agents induce double strand DNA breaks (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Homo sapiens)
LIG3 ligates NEIL1,NEIL2-generated single strand break (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
PCNA-Dependent Long Patch Base Excision Repair (Homo sapiens)
LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
POLB-Dependent Long Patch Base Excision Repair (Homo sapiens)
LIG1 and POLB dissociate from repaired dsDNA (Homo sapiens)
LIG1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
LIG1 bound to POLB ligates SSB (Homo sapiens)
LIG1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
Resolution of AP sites via the single-nucleotide replacement pathway (Homo sapiens)
Dissociation of LIG3:XRCC1 complex from the BER site (Homo sapiens)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Homo sapiens)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
DNA Damage Reversal (Homo sapiens)
MGMT-mediated DNA damage reversal (Homo sapiens)
MGMT/hAGT mediated DNA Damage Reversal (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
Reversal of alkylation damage by DNA dioxygenases (Homo sapiens)
ALKBH2 mediated reversal of alkylation damage (Homo sapiens)
Oxidative dealkylation of 1-etA damaged DNA By ALKBH2 (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
Oxidative demethylation of 1-meA damaged DNA by ALKBH2 (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
Oxidative demethylation of 3-meC damaged DNA by ALKBH2 (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
ALKBH3 mediated reversal of alkylation damage (Homo sapiens)
Oxidative dealkylation of 1-EtA damaged DNA by ABH3 (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
Oxidative demethylation of 1-meA damaged DNA By ALKBH3 (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
Oxidative demethylation of 3-meC damaged DNA By ALKBH3 (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Sensing of DNA Double Strand Breaks (Homo sapiens)
DSB inducing agents induce double strand DNA breaks (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
Resolution of D-Loop Structures (Homo sapiens)
Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
BLM mediates dissolution of double Holliday junction (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
Gap-filling DNA synthesis in SDSA (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
Nonhomologous End-Joining (NHEJ) (Homo sapiens)
XRCC4:LIG4 ligates DNA DSB ends during NHEJ (Homo sapiens)
ds DNA, mutated dsDNA [nucleoplasm] (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
dsDNA [nucleoplasm] (Homo sapiens)
Participant Of
output
BLM mediates dissolution of double Holliday junction
Dissociation of LIG3:XRCC1 complex from the BER site
Gap-filling DNA synthesis in SDSA
LIG1 and POLB dissociate from repaired dsDNA
LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA
LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site
Ligation of newly synthesized repair patch to incised DNA in GG-NER
MGMT/hAGT mediated DNA Damage Reversal
Oxidative dealkylation of 1-EtA damaged DNA by ABH3
Oxidative dealkylation of 1-etA damaged DNA By ALKBH2
Oxidative demethylation of 1-meA damaged DNA by ALKBH2
Oxidative demethylation of 1-meA damaged DNA By ALKBH3
Oxidative demethylation of 3-meC damaged DNA by ALKBH2
Oxidative demethylation of 3-meC damaged DNA By ALKBH3
Recovery of RNA synthesis after TC-NER
hasComponent
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm]
LIG1:POLB:dsDNA [nucleoplasm]
LIG3:XRCC1:POLB:dsDNA [nucleoplasm]
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm]
hasMember
ds DNA, mutated dsDNA [nucleoplasm]
input
DSB inducing agents induce double strand DNA breaks
Inferred To
Ghost homologue of dsDNA [nucleoplasm] (Canis familiaris)
Ghost homologue of dsDNA [nucleoplasm] (Danio rerio)
Ghost homologue of dsDNA [nucleoplasm] (Dictyostelium discoideum)
Ghost homologue of dsDNA [nucleoplasm] (Drosophila melanogaster)
Ghost homologue of dsDNA [nucleoplasm] (Mus musculus)
Ghost homologue of dsDNA [nucleoplasm] (Rattus norvegicus)
Ghost homologue of dsDNA [nucleoplasm] (Schizosaccharomyces pombe)
Ghost homologue of dsDNA [nucleoplasm] (Sus scrofa)
Ghost homologue of dsDNA [nucleoplasm] (Xenopus tropicalis)
Cross References
ChEBI
16991
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