lestaurtinib-resistant FLT3 mutants don't bind lestaurtinib

Stable Identifier
R-HSA-9702593
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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lestaurtinib-resistant FLT3 mutants don't bind lestaurtinib
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The following FLT3 mutant is resistant to inhibition by lestaurtinib:

FLT3 A627P (Williams et al, 2013)

Literature References
PubMed ID Title Journal Year
22858906 Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors

Williams, AB, Nguyen, B, Li, L, Brown, P, Levis, M, Leahy, D, Small, D

Leukemia 2013
Participants
Input
Participant Of
hasEvent
Normal reaction
FLT3 binds type I TKI (Homo sapiens)
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-10-01)
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