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Active ALK dimer [plasma membrane]
Stable Identifier
R-HSA-9850879
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
ALK autophosphorylation (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
ALK-stimulated MYCN gene expression (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK binds FRS2 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:FRS2 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK binds JAK3 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK binds PLCG1 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK binds SHC1 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:SHC1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK binds SRC (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:SRC [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK dimer binds IRS1 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:IRS1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK phosphorylates FRS2 (Homo sapiens)
Active ALK:FRS2 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:p-6Y FRS2 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK phosphorylates IRS1 (Homo sapiens)
Active ALK:IRS1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:pY-IRS1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK phosphorylates JAK3 (Homo sapiens)
Active ALK:JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:p-Y980 JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK phosphorylates PLCG1 (Homo sapiens)
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:p-4Y PLCG1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK phosphorylates SHC1 (Homo sapiens)
Active ALK:SHC1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:p-3Y SHC1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK phosphorylates SRC (Homo sapiens)
Active ALK:SRC [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:p-Y419 SRC [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK recruits PI3K (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:PI3K [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)
Active ALK:PI3K [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
PTPN6 dephosphorylates JAK3 (Homo sapiens)
Active ALK:JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Active ALK:p-Y980 JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
STAT3 is phosphorylated downstream of active ALK (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
Participants
members
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane]
(Homo sapiens)
candidates
MDK:p-7Y ALK dimer [plasma membrane]
(Homo sapiens)
PTN:p-7Y ALK dimer [plasma membrane]
(Homo sapiens)
Participates
as an input of
Active ALK binds SRC (Homo sapiens)
Active ALK recruits PI3K (Homo sapiens)
Active ALK binds PLCG1 (Homo sapiens)
Active ALK dimer binds IRS1 (Homo sapiens)
Active ALK binds SHC1 (Homo sapiens)
Active ALK binds JAK3 (Homo sapiens)
Active ALK binds FRS2 (Homo sapiens)
STAT3 is phosphorylated downstream of active ALK (Homo sapiens)
as a component of
Active ALK:p-Y419 SRC [plasma membrane] (Homo sapiens)
Active ALK:SRC [plasma membrane] (Homo sapiens)
Active ALK:PI3K [plasma membrane] (Homo sapiens)
Active ALK:p-4Y PLCG1 [plasma membrane] (Homo sapiens)
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
Active ALK:pY-IRS1 [plasma membrane] (Homo sapiens)
Active ALK:IRS1 [plasma membrane] (Homo sapiens)
Active ALK:p-3Y SHC1 [plasma membrane] (Homo sapiens)
Active ALK:SHC1 [plasma membrane] (Homo sapiens)
Active ALK:JAK3 [plasma membrane] (Homo sapiens)
Active ALK:p-Y980 JAK3 [plasma membrane] (Homo sapiens)
Active ALK:p-6Y FRS2 [plasma membrane] (Homo sapiens)
Active ALK:FRS2 [plasma membrane] (Homo sapiens)
as an output of
ALK autophosphorylation (Homo sapiens)
This entity regulates
Positively
ALK-stimulated MYCN gene expression
(Homo sapiens)
Inferred To
Active ALK dimer [plasma membrane]
(Bos taurus)
Active ALK dimer [plasma membrane]
(Canis familiaris)
Active ALK dimer [plasma membrane]
(Danio rerio)
Active ALK dimer [plasma membrane]
(Gallus gallus)
Active ALK dimer [plasma membrane]
(Mus musculus)
Active ALK dimer [plasma membrane]
(Rattus norvegicus)
Active ALK dimer [plasma membrane]
(Sus scrofa)
Ghost homologue of Active ALK dimer [plasma membrane]
(Caenorhabditis elegans)
Ghost homologue of Active ALK dimer [plasma membrane]
(Drosophila melanogaster)
Ghost homologue of Active ALK dimer [plasma membrane]
(Xenopus tropicalis)
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