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ALK F1174V dimer [plasma membrane]
Stable Identifier
R-HSA-9700005
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
ALK mutants bind TKIs (Homo sapiens)
ALK mutants bind type I TKIs (Homo sapiens)
type I ALK-binding TKIs:type I-sensitive ALK mutants [cytosol] (Homo sapiens)
type I TKI sensitive ALK mutants [plasma membrane] (Homo sapiens)
alectinib sensitve ALK mutants [plasma membrane] (Homo sapiens)
ALK F1174V dimer [plasma membrane] (Homo sapiens)
brigatinib-sensitive ALK mutants [plasma membrane] (Homo sapiens)
ALK F1174V dimer [plasma membrane] (Homo sapiens)
ceritinib-sensitive ALK mutants [plasma membrane] (Homo sapiens)
ALK F1174V dimer [plasma membrane] (Homo sapiens)
crizotinib-sensitive ALK mutants [cytosol] (Homo sapiens)
ALK F1174V dimer [plasma membrane] (Homo sapiens)
type I TKI sensitive ALK mutants [plasma membrane] (Homo sapiens)
alectinib sensitve ALK mutants [plasma membrane] (Homo sapiens)
ALK F1174V dimer [plasma membrane] (Homo sapiens)
brigatinib-sensitive ALK mutants [plasma membrane] (Homo sapiens)
ALK F1174V dimer [plasma membrane] (Homo sapiens)
ceritinib-sensitive ALK mutants [plasma membrane] (Homo sapiens)
ALK F1174V dimer [plasma membrane] (Homo sapiens)
crizotinib-sensitive ALK mutants [cytosol] (Homo sapiens)
ALK F1174V dimer [plasma membrane] (Homo sapiens)
Drug resistance of ALK mutants (Homo sapiens)
ceritinib-resistant ALK mutants (Homo sapiens)
ceritinib-resistant ALK mutants don't bind ceritinib (Homo sapiens)
ceritinib-resistant ALK mutants [plasma membrane] (Homo sapiens)
ALK F1174V dimer [plasma membrane] (Homo sapiens)
crizotinib-resistant ALK mutants (Homo sapiens)
crizotinib-resistant ALK mutants don't bind crizotinib (Homo sapiens)
crizotinib resistant ALK mutants [plasma membrane] (Homo sapiens)
ALK F1174V dimer [plasma membrane] (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Autophosphorylation of point mutants of ALK (Homo sapiens)
ALK point mutant dimers [plasma membrane] (Homo sapiens)
kinase domain ALK mutant dimers [plasma membrane] (Homo sapiens)
ALK F1174V dimer [plasma membrane] (Homo sapiens)
Ligand-independent dimerization of point mutants of ALK (Homo sapiens)
ALK point mutant dimers [plasma membrane] (Homo sapiens)
kinase domain ALK mutant dimers [plasma membrane] (Homo sapiens)
ALK F1174V dimer [plasma membrane] (Homo sapiens)
Participants
components
x 2
ALK F1174V [plasma membrane]
(Homo sapiens)
Participates
as a candidate of
kinase domain ALK mutant dimers [plasma membrane] (Homo sapiens)
as a member of
ceritinib-resistant ALK mutants [plasma membrane] (Homo sapiens)
crizotinib resistant ALK mutants [plasma membrane] (Homo sapiens)
alectinib sensitve ALK mutants [plasma membrane] (Homo sapiens)
brigatinib-sensitive ALK mutants [plasma membrane] (Homo sapiens)
crizotinib-sensitive ALK mutants [cytosol] (Homo sapiens)
ceritinib-sensitive ALK mutants [plasma membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
non-small cell lung carcinoma
DOID:3908
Non-small cell lung cancer (disorder), NSCLC, NSCLC
neuroblastoma
DOID:769
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