alectinib sensitve ALK mutants [plasma membrane]

Stable Identifier
R-HSA-9700555
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
26372962 Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors

Davare, MA, Vellore, NA, Wagner, JP, Eide, CA, Goodman, JR, Drilon, A, Deininger, MW, O'Hare, T, Druker, BJ

Proc. Natl. Acad. Sci. U.S.A. 2015
26464158 ALK F1174V mutation confers sensitivity while ALK I1171 mutation confers resistance to alectinib. The importance of serial biopsy post progression

Ou, SH, Milliken, JC, Azada, MC, Miller, VA, Ali, SM, Klempner, SJ

Lung Cancer 2016
25421750 Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma

Ceccon, M, Mologni, L, Giudici, G, Piazza, R, Pirola, A, Fontana, D, Gambacorti-Passerini, C

Mol. Cancer Res. 2015
25393796 Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib

Ou, SH, Klempner, SJ, Greenbowe, JR, Azada, M, Schrock, AB, Ali, SM, Ross, JS, Stephens, PJ, Miller, VA

J Thorac Oncol 2014
Participants
members
Participates
as a member of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
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