EML4(1-223)insKMSTREKNSQV-p-7Y-ALK(1059-1620) fusion [cytosol]

Stable Identifier
R-HSA-9699885
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Echinoderm microtubule-associated protein-like 4, EMAL4_HUMAN, variant 3b
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
18593892 Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer

Ishikawa, Y, Watanabe, H, Hatanaka, H, Soda, M, Sugiyama, Y, Ueno, T, Takada, S, Choi, YL, Yamashita, Y, Inamura, K, Hamada, T, Haruta, H, Togashi, Y, Hatano, S, Takeuchi, K, Enomoto, M, Mano, H, Kurashina, K

Cancer Res. 2008
External Reference Information
External Reference
UniProt:Q9HC35 EML4
Gene Names
EML4, C2orf2, EMAPL4
Chain
chain:1-981
Reference Genes
BioGPS Gene:27436 EML4
COSMIC (genes):EML4 EML4
CTD Gene:27436 EML4
dbSNP Gene:27436 EML4
ENSEMBL:ENSG00000143924 EML4
ENSEMBL_homo_sapiens_GENE:ENSG00000143924.19 EML4
HGNC:1316 EML4
KEGG Gene (Homo sapiens):27436 EML4
Monarch:27436 EML4
NCBI Gene:27436 EML4
OMIM:607442 EML4
UCSC:Q9HC35 EML4
Reference Transcript
Other Identifiers
11716652_a_at
11716653_x_at
11716654_a_at
11747005_a_at
16879408
220386_PM_s_at
220386_s_at
223068_PM_at
223068_at
223069_PM_s_at
223069_s_at
228674_PM_s_at
228674_s_at
2478749
2478750
2478751
2478771
2478772
2478776
2478778
2478780
2478787
2478789
2478791
2478794
2478797
2478801
2478802
2478805
2478806
2478807
2478808
2478810
2478816
2478818
2478826
2478829
2478830
2478833
2478834
2478835
2478836
2478837
2478838
2478839
2478840
2478841
2478842
2478843
2478844
27436
56562_at
8041592
88181_at
A_14_P131775
A_23_P143127
A_24_P273413
GE55919
GO:0000226
GO:0000278
GO:0003674
GO:0005515
GO:0005737
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0007010
GO:0007017
GO:0007049
GO:0007059
GO:0007080
GO:0008017
GO:0008092
GO:0008608
GO:0015630
GO:0016020
GO:0030496
GO:0043014
GO:0043226
GO:0043621
GO:0048487
GO:0051301
GO:0072686
GO:0140014
HMNXSV003035398
HMNXSV003044133
Hs.13472.1.A2_3p_at
ILMN_1718297
PH_hs_0024383
TC02000260.hg
g9506630_3p_a_at
g9957235_3p_a_at
Participates
as a component of
Other forms of this molecule
EML4 [cytosol]
p-S,T-EML4 [cytosol]
EML4(1-496)-ALK(1058-1620) fusion [cytosol]
EML4(1-223)-ALK(1059-1620) fusion [cytosol]
EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol]
EML4(1-780)-p-7Y-ALK(1058-1620) fusion [cytosol]
EML4(1-569)-p-7Y-ALK(1078-1620) fusion [cytosol]
EML4(1-223)-p-7Y-ALK(1059-1620) fusion [cytosol]
EML4(1-486)-p-7Y-ALK(1058-1620) fusion [cytosol]
EML4(1-569)-ALK(1078-1620) fusion [cytosol]
EML4(1-780)-ALK(1058-1620) fusion [cytosol]
Modified Residues
Name
Insertion of residues 1059 to 1620 at 224 from UniProt:Q9UM73 ALK
Coordinate
224
Name
Replacement of residues 223 to 223 by EKMSTREKNSQV
Name
O4'-phospho-L-tyrosine at 1278
Coordinate
1278
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1282
Coordinate
1282
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1283
Coordinate
1283
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1096
Coordinate
1096
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1358
Coordinate
1358
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1507
Coordinate
1507
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1604
Coordinate
1604
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
Cross References
RefSeq
OpenTargets
HPA
GeneCards
Ensembl
PRO
Pharos - Targets
PDB
Interactors (8)
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