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NS1 Mediated Effects on Host Pathways
Stable Identifier
R-HSA-168276
Type
Pathway
Species
Homo sapiens
Related Species
Influenza A virus
ReviewStatus
5/5
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Influenza Infection (Homo sapiens)
NS1 Mediated Effects on Host Pathways (Homo sapiens)
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Viral NS1 protein is a nuclear, dimeric protein that is highly expressed in infected cells and has dsRNA-binding activity. The RNA-binding domain lies within the N-terminal portion of the protein. The NS1 RNA-binding domain forms a symmetric homodimer with a six-helical fold. Mutational analysis has demonstrated that dimer formation is crucial for RNA-binding. The basic residues are believed to make contact with the phosphate backbone of the RNA which is consistent with an observed lack of sequence specificity. Neither NS1 nor its bound RNA undergo any significant structural changes upon binding. The NS1 dimer spans the minor groove of canonical A-form dsRNA. The non-RNA binding portion of NS1 has been termed the effector domain and includes binding sites for host cell poly (A)-binding protein II (PABII) and the 30kDa subunit of cleavage and polyadenylation specificity factor (CPSF).
Literature References
PubMed ID
Title
Journal
Year
0
Orthomyxoviridae: The Viruses and Their Replication
Shaw, ML
,
Palese, P
Fields Virology, 5th edition D.M. Knipe and P.M. Howley, Editors. 2006, Lippencott Williams and Wilkins: Philadelphia ISBN-10: 0-7817-6060-7
2001
Participants
Events
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
(Homo sapiens)
Release of NS1 homodimer
(Homo sapiens)
Inhibition of Host mRNA Processing and RNA Silencing
(Homo sapiens)
Inhibition of Interferon Synthesis
(Homo sapiens)
Inhibition of PKR
(Homo sapiens)
Participates
as an event of
Influenza Infection (Homo sapiens)
Event Information
Go Biological Process
modulation by virus of host cellular process (0019054)
Disease
Name
Identifier
Synonyms
influenza
DOID:8469
Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Gillespie, ME (2013-11-18)
Reviewed
Gale M, Jr (2004-05-12)
Created
Gillespie, ME (2005-11-14)
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