The ATF5 mRNA is translated to yield ATF5 protein (Watatani et al. 2008, and inferred from the mouse homolog) which is then imported into the nucleus. The ATF5 mRNA contains 2 upstream ORFs (uORFs) which inhibit translation of the downstream ATF5 coding region (Watatani et al. 2008). Translation of uORF2 also targets the mRNA for nonsense-mediated decay (Hatano et al. 2013). During stresses such as amino acid limitation and arsenite-induced oxidative stress, EIF2S1 (eIF2-alpha) is phosphorylated, decreasing translation initiation at the uORFs and increasing translation of ATF5 (Watatani et al. 2008, and inferred from the mouse homolog).
Watatani, Y, Ichikawa, K, Nakanishi, N, Fujimoto, M, Takeda, H, Kimura, N, Hirose, H, Takahashi, S, Takahashi, Y
Hatano, M, Umemura, M, Kimura, N, Yamazaki, T, Takeda, H, Nakano, H, Takahashi, S, Takahashi, Y
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