Translation of ATF5

Stable Identifier
R-HSA-9653745
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Translation of ATF5
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The ATF5 mRNA is translated to yield ATF5 protein (Watatani et al. 2008, and inferred from the mouse homolog) which is then imported into the nucleus. The ATF5 mRNA contains 2 upstream ORFs (uORFs) which inhibit translation of the downstream ATF5 coding region (Watatani et al. 2008). Translation of uORF2 also targets the mRNA for nonsense-mediated decay (Hatano et al. 2013). During stresses such as amino acid limitation and arsenite-induced oxidative stress, EIF2S1 (eIF2-alpha) is phosphorylated, decreasing translation initiation at the uORFs and increasing translation of ATF5 (Watatani et al. 2008, and inferred from the mouse homolog).
Literature References
PubMed ID Title Journal Year
23876217 The 5'-untranslated region regulates ATF5 mRNA stability via nonsense-mediated mRNA decay in response to environmental stress

Hatano, M, Umemura, M, Kimura, N, Yamazaki, T, Takeda, H, Nakano, H, Takahashi, S, Takahashi, Y

FEBS J. 2013
18055463 Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region

Watatani, Y, Ichikawa, K, Nakanishi, N, Fujimoto, M, Takeda, H, Kimura, N, Hirose, H, Takahashi, S, Takahashi, Y

J. Biol. Chem. 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Inferred From
Translation of Atf5 (Mus musculus)
Authored
May, B  (2019-07-14)
Reviewed
Chen, JJ  (2019-10-22)
Created
May, B  (2019-07-15)
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