Translation of ATF5

Stable Identifier
Reaction [omitted]
Homo sapiens
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The ATF5 mRNA is translated to yield ATF5 protein (Watatani et al. 2008, and inferred from the mouse homolog) which is then imported into the nucleus. The ATF5 mRNA contains 2 upstream ORFs (uORFs) which inhibit translation of the downstream ATF5 coding region (Watatani et al. 2008). Translation of uORF2 also targets the mRNA for nonsense-mediated decay (Hatano et al. 2013). During stresses such as amino acid limitation and arsenite-induced oxidative stress, EIF2S1 (eIF2-alpha) is phosphorylated, decreasing translation initiation at the uORFs and increasing translation of ATF5 (Watatani et al. 2008, and inferred from the mouse homolog).

Literature References
PubMed ID Title Journal Year
23876217 The 5'-untranslated region regulates ATF5 mRNA stability via nonsense-mediated mRNA decay in response to environmental stress

Yamazaki, T, Takahashi, S, Takeda, H, Hatano, M, Umemura, M, Takahashi, Y, Kimura, N, Nakano, H

FEBS J. 2013
18055463 Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region

Takahashi, S, Takeda, H, Ichikawa, K, Nakanishi, N, Hirose, H, Takahashi, Y, Kimura, N, Fujimoto, M, Watatani, Y

J. Biol. Chem. 2008
This event is regulated
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