Translation of Atf5

Stable Identifier
R-MMU-9653710
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Translation of Atf5
The Atf5 mRNA is translated to yield Atf5 protein (Zhou et al. 2008, Zhang et al. 2019) which is then imported into the nucleus. The Atf5 mRNA contains 2 upstream ORFs (uORFs) which inhibit translation of the downstream Atf5 coding region (Zhou et al. 2008). During certain stresses, Eif2s1 (eIF2-alpha) is phosphorylated, decreasing translation initiation at the uORFs and increasing translation of Atf5 (Zhou et al. 2008, Zhang et al. 2019).
Literature References
PubMed ID Title Journal Year
31033440 HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Macias-Garcia, A, Zhang, S, Butty, VL, Levine, SS, Sankaran, VG, Velazquez, J, Ulirsch, JC, Chen, JJ

Elife 2019
18195013 Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions

Zhou, D, Jiang, L, Palam, LR, Wek, RC, Narasimhan, J, Staschke, KA

J. Biol. Chem. 2008
Participants
Input
Output
This event is regulated
Positively by
Regulator
p-S52-Eif2s1:Eif2s2:Eif2s3 [cytosol] (Mus musculus)
Orthologous Events
Translation of ATF5 (Homo sapiens)
Authored
May, B  (2019-07-14)
Reviewed
Chen, JJ  (2019-10-22)
Created
May, B  (2019-07-15)
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