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p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
Stable Identifier
R-HSA-9633006
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to mitochondrial stress (Homo sapiens)
DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
Translation of ATF4 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Translation of DDIT3 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
Translation of ATF4 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Translation of ATF5 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Translation of DDIT3 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Translation of PPP1R15A (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Translation of ATF4 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
p-PKR dimer phosphorylates eIF2-alpha (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Participants
components
EIF2S2 [cytosol]
(Homo sapiens)
EIF2S3 [cytosol]
(Homo sapiens)
p-S52-EIF2S1 [cytosol]
(Homo sapiens)
Participates
as an output of
p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Homo sapiens)
p-PKR dimer phosphorylates eIF2-alpha (Homo sapiens)
This entity regulates
Positively
Translation of PPP1R15A
(Homo sapiens)
Translation of ATF5
(Homo sapiens)
Translation of DDIT3
(Homo sapiens)
Translation of ATF4
(Homo sapiens)
Inferred From
p-S52-SUI2:SUI3:GCD11 [cytosol]
(Saccharomyces cerevisiae)
p-S52-Eif2s1:Eif2s2:Eif2s3 [cytosol]
(Mus musculus)
Inferred To
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Bos taurus)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Caenorhabditis elegans)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Canis familiaris)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Danio rerio)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Dictyostelium discoideum)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Drosophila melanogaster)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Gallus gallus)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Mus musculus)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Plasmodium falciparum)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Rattus norvegicus)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Saccharomyces cerevisiae)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Schizosaccharomyces pombe)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Sus scrofa)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Xenopus tropicalis)
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