Blockage of phagosome acidification

Stable Identifier
R-HSA-9636467
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
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Acidification of the phagosome occurs by insertion of ATPases into the phagosomal membrane in preparation for fusion with lysosomes. The pH of phagosomes containing Mtb never drops below 6.5 due to Mtb interfering with several acidification mechanisms (Queval et al. 2017).

Literature References
PubMed ID Title Journal Year
28954234 Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling

Queval, CJ, Song, OR, Carralot, JP, Saliou, JM, Bongiovanni, A, Deloison, G, Deboosère, N, Jouny, S, Iantomasi, R, Delorme, V, Debrie, AS, Park, SJ, Gouveia, JC, Tomavo, S, Brosch, R, Yoshimura, A, Yeramian, E, Brodin, P

Cell Rep 2017
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created