Inhibition of nitric oxide production

Stable Identifier
R-HSA-9636249
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
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Phagocytes produce nitric oxide to damage interned bacteria before fusion of the phagosome with lysosomes. While Mtb has several pathways to neutralize NO it also attempts to block the host enzymes used for NO production (Fang 2004, Bhat 2017).

Literature References
PubMed ID Title Journal Year
28071726 The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide production

Bhat, KH, Srivastava, S, Kotturu, SK, Ghosh, S, Mukhopadhyay, S

Sci Rep 2017
15378046 Antimicrobial reactive oxygen and nitrogen species: concepts and controversies

Fang, FC

Nat Rev Microbiol 2004
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
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