Infection with Mycobacterium tuberculosis

Stable Identifier
R-HSA-9635486
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Infection with Mycobacterium tuberculosis (Mtb) is soon countered by the host's immune system, the organism is however almost never eradicated; ten per cent of infections will develop into "open tuberculosis", while the other ninety per cent become "latent", a state that can persist for decades until loss of immune control. Approximately 25% of the world's population is estimated to harbour latent tuberculosis. Latent infection involves the bacterium being internalized by phagocytes where it stops and counters the innate immune answer (Russell 2011, Russell et al. 2010). When a status-quo is reached, Mtb enters a non-replicating persistent state (Barry et al. 2009, Boshoff & Barry 2005). Weakening of the immune defense sooner or later enables the waking up and multiplication of the bacterium inside the phagocyte, necrosis of the cell, and escape, analogous to the burst of lytic viruses (Repasy 2013).

Literature References
PubMed ID Title Journal Year
21349098 Mycobacterium tuberculosis and the intimate discourse of a chronic infection

Russell, DG

Immunol Rev 2011
23436998 Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo

Kotton, DN, Repasy, T, Martinez, N, Hendricks, G, Kornfeld, H, Kirschner, DE, Marino, S, Wilson, AA, Baker, S, Lee, J

PLoS Pathog. 2013
19855401 The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

Flynn, J, Ehrt, S, Dartois, V, Dick, T, Wilkinson, RJ, Boshoff, HI, Barry CE, 3rd, Schnappinger, D, Young, D

Nat Rev Microbiol 2009
20466922 Tuberculosis: what we don't know can, and does, hurt us

Flynn, JL, Russell, DG, Barry CE, 3rd

Science 2010
15608701 Tuberculosis - metabolism and respiration in the absence of growth

Boshoff, HI, Barry CE, 3rd

Nat Rev Microbiol 2005
Participants
Participates
Event Information
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
GlyCosmos
Authored
Reviewed
Created
Cite Us!