Antimicrobial action and antimicrobial resistance in Mtb

Stable Identifier
R-HSA-9639775
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
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Antimicrobial compounds kill microorganisms or inhibit their growth, either in the host, outside on the skin (antiseptics), or in the environment (disinfectants). In the host they are named after the target symbiont, for example antibiotics, antifungals, and antiparasitics. It suffices to permanently stop an essential pathway in the symbiont to kill it. Broad spectrum antimicrobials usually target a conserved pathway like protein synthesis or cell wall construction, in order to affect a whole taxonomic group (Arenz & Wilson 2016, Barry et al. 2007, Green 2002).

Resistance of microorganisms (bacteria, viruses, parasites) to antimicrobials is one of the most important public health problems. Many mechanisms exist, and they are either acquired by mutation, by horizontal gene transfer, or are already intrinsic to the organism. The main mechanisms are modification of the antimicrobial, or its removal from the place of action, modification of its binding partner in the affected pathway, or usage of a back-up pathway. Participation of the organism in a consortium (like in biofilms) enables additional resistance mechanisms (Aminov & Mackie 2007, Peterson & Kaur 2018, van Acker et al. 2014, van Acker & Coenye 2016).

The events described here are specific to Mtb infection.

Literature References
PubMed ID Title Journal Year
27129224 The Role of Efflux and Physiological Adaptation in Biofilm Tolerance and Resistance

Van Acker, H, Coenye, T

J. Biol. Chem. 2016
17490428 Evolution and ecology of antibiotic resistance genes

Aminov, RI, Mackie, RI

FEMS Microbiol. Lett. 2007
30555448 Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens

Peterson, E, Kaur, P

Front Microbiol 2018
17970228 Targeting the formation of the cell wall core of M. tuberculosis

Barry, CE, Crick, DC, McNeil, MR

Infect Disord Drug Targets 2007
24598086 Molecular mechanisms of antimicrobial tolerance and resistance in bacterial and fungal biofilms

Van Acker, H, Van Dijck, P, Coenye, T

Trends Microbiol. 2014
11901475 The bacterial cell wall as a source of antibacterial targets

Green, DW

Expert Opin. Ther. Targets 2002
27481773 Bacterial Protein Synthesis as a Target for Antibiotic Inhibition

Arenz, S, Wilson, DN

Cold Spring Harb Perspect Med 2016
Participants
Participates
Event Information
Go Biological Process
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
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