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Modulation by Mtb of host immune system
Stable Identifier
R-HSA-9637628
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
ReviewStatus
5/5
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Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Modulation by Mtb of host immune system (Homo sapiens)
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Mtb enhances its chances for being taken up by a phagocyte by blocking adaptive immune responses, as well as other innate immune system responses. Components of the bacterial cell wall also specifically promote phagocytosis via both the opsonic pathway and the presentation of adhesins (Esparza et al. 2015).
Literature References
PubMed ID
Title
Journal
Year
25359607
PstS-1, the 38-kDa Mycobacterium tuberculosis glycoprotein, is an adhesin, which binds the macrophage mannose receptor and promotes phagocytosis
Zenteno, E
,
GarcĂa, T
,
Esparza, M
,
Mancilla, R
,
Espinosa, P
,
Palomares, B
Scand. J. Immunol.
2015
Participants
Events
PstS1 binds MRC1
(Homo sapiens)
EsxA translocates from Mtb cytosol to the host's ER
(Homo sapiens)
EsxA binds TLR2
(Homo sapiens)
Rv2779c binds TLR2
(Homo sapiens)
EsxA binds B2M
(Homo sapiens)
PtpA binds Ubiquitin
(Homo sapiens)
Participates
as an event of
Infection with Mycobacterium tuberculosis (Homo sapiens)
Event Information
Go Biological Process
symbiont-mediated perturbation of host defense response (0052031)
Disease
Name
Identifier
Synonyms
tuberculosis
DOID:399
tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R (2019-02-19)
Reviewed
Wilkinson, RJ (2019-10-23)
Deffur, A (2019-10-23)
Created
Pardo, AM (2019-02-19)
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