Escape of Mtb from the phagocyte

Stable Identifier
Homo sapiens
Related Species
Mycobacterium tuberculosis
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

The relatively constant numbers of Mycobacterium tuberculosis (Mtb) during the chronic phase of infection are due to a balance between rapid replication and death (McDaniel et al. 2016). The relatively safe environment for Mtb in the phagocyte's phagosome is overcome when about 20-25 bacterial cells accumulate (Repasy et al. 2013). First, the phagosomal membrane is destroyed. Then, by injuring mitochondria and depleting NAD+, cell necrosis is started, resulting in Mtb escape (Lee et al. 2011).

Literature References
PubMed ID Title Journal Year
23436998 Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo

Kotton, DN, Repasy, T, Martinez, N, Hendricks, G, Kornfeld, H, Kirschner, DE, Marino, S, Wilson, AA, Baker, S, Lee, J

PLoS Pathog. 2013
27379030 Quantifying Limits on Replication, Death, and Quiescence of Mycobacterium tuberculosis in Mice

Eda, S, Ganusov, VV, Krishna, N, McDaniel, MM, Handagama, WG

Front Microbiol 2016
21483832 Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages

Repasy, T, Papavinasasundaram, K, Kornfeld, H, Sassetti, C, Lee, J

PLoS ONE 2011
Event Information
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cite Us!