Escape of Mtb from the phagocyte

Stable Identifier
R-HSA-9637679
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
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The relatively constant numbers of Mycobacterium tuberculosis (Mtb) during the chronic phase of infection are due to a balance between rapid replication and death (McDaniel et al. 2016). The relatively safe environment for Mtb in the phagocyte's phagosome is overcome when about 20-25 bacterial cells accumulate (Repasy et al. 2013). First, the phagosomal membrane is destroyed. Then, by injuring mitochondria and depleting NAD+, cell necrosis is started, resulting in Mtb escape (Lee et al. 2011).

Literature References
PubMed ID Title Journal Year
27379030 Quantifying Limits on Replication, Death, and Quiescence of Mycobacterium tuberculosis in Mice

McDaniel, MM, Krishna, N, Handagama, WG, Eda, S, Ganusov, VV

Front Microbiol 2016
23436998 Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo

Repasy, T, Lee, J, Marino, S, Martinez, N, Kirschner, DE, Hendricks, G, Baker, S, Wilson, AA, Kotton, DN, Kornfeld, H

PLoS Pathog. 2013
21483832 Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages

Lee, J, Repasy, T, Papavinasasundaram, K, Sassetti, C, Kornfeld, H

PLoS ONE 2011
Participants
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Event Information
Go Biological Process
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
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