RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1

Stable Identifier
R-HSA-9634418
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Based on activation of RAS signaling by autophosphorylated ERBB2 homodimers, as well as binding of GRB2 and SHC1 to ERBB2 homodimers (Pickl and Ries 2009), it is assumed that SOS1, recruited to ERBB2 homodimers through GRB2, mediates GDP to GTP exchange on RAS protein family, resulting in formation of the active RAS:GTP complex.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of p-ERBB2 homodimer:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]
Physical Entity
Activity
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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