RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1

Stable Identifier
R-HSA-9634418
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1
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Based on activation of RAS signaling by autophosphorylated ERBB2 homodimers, as well as binding of GRB2 and SHC1 to ERBB2 homodimers (Pickl and Ries 2009), it is assumed that SOS1, recruited to ERBB2 homodimers through GRB2, mediates GDP to GTP exchange on RAS protein family, resulting in formation of the active RAS:GTP complex.
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-ERBB2 homodimer:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]

Physical Entity
p-ERBB2 homodimer:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Normal reaction
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers (Homo sapiens)
Functional status

Increased translational product level of p-ERBB2 homodimer:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2019-07-31)
Reviewed
Kancha, RK  (2019-09-16)
Created
Orlic-Milacic, M  (2019-01-10)
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