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SGCA [plasma membrane]
Stable Identifier
R-HSA-9630720
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Alpha-sarcoglycan, SGCA_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Formation of the dystrophin-glycoprotein complex (DGC) (Homo sapiens)
DGC complex binds AGRN and HSPG2 (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
DGC complex:laminins [plasma membrane] (Homo sapiens)
DGC [plasma membrane] (Homo sapiens)
SGC:DAG1:SSPN complex [plasma membrane] (Homo sapiens)
SGCB:SGCD:SGCD,SGCZ:SGCA,SGCE [plasma membrane] (Homo sapiens)
SGCA, SGCE [plasma membrane] (Homo sapiens)
SGCA [plasma membrane] (Homo sapiens)
DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
DGC complex:laminins [plasma membrane] (Homo sapiens)
DGC [plasma membrane] (Homo sapiens)
SGC:DAG1:SSPN complex [plasma membrane] (Homo sapiens)
SGCB:SGCD:SGCD,SGCZ:SGCA,SGCE [plasma membrane] (Homo sapiens)
SGCA, SGCE [plasma membrane] (Homo sapiens)
SGCA [plasma membrane] (Homo sapiens)
DGC complex binds laminins (Homo sapiens)
DGC [plasma membrane] (Homo sapiens)
SGC:DAG1:SSPN complex [plasma membrane] (Homo sapiens)
SGCB:SGCD:SGCD,SGCZ:SGCA,SGCE [plasma membrane] (Homo sapiens)
SGCA, SGCE [plasma membrane] (Homo sapiens)
SGCA [plasma membrane] (Homo sapiens)
DGC complex:laminins [plasma membrane] (Homo sapiens)
DGC [plasma membrane] (Homo sapiens)
SGC:DAG1:SSPN complex [plasma membrane] (Homo sapiens)
SGCB:SGCD:SGCD,SGCZ:SGCA,SGCE [plasma membrane] (Homo sapiens)
SGCA, SGCE [plasma membrane] (Homo sapiens)
SGCA [plasma membrane] (Homo sapiens)
DGC:laminin complex binds F-actin (Homo sapiens)
DGC complex:laminins [plasma membrane] (Homo sapiens)
DGC [plasma membrane] (Homo sapiens)
SGC:DAG1:SSPN complex [plasma membrane] (Homo sapiens)
SGCB:SGCD:SGCD,SGCZ:SGCA,SGCE [plasma membrane] (Homo sapiens)
SGCA, SGCE [plasma membrane] (Homo sapiens)
SGCA [plasma membrane] (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
DGC complex:laminins [plasma membrane] (Homo sapiens)
DGC [plasma membrane] (Homo sapiens)
SGC:DAG1:SSPN complex [plasma membrane] (Homo sapiens)
SGCB:SGCD:SGCD,SGCZ:SGCA,SGCE [plasma membrane] (Homo sapiens)
SGCA, SGCE [plasma membrane] (Homo sapiens)
SGCA [plasma membrane] (Homo sapiens)
Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC (Homo sapiens)
DGC [plasma membrane] (Homo sapiens)
SGC:DAG1:SSPN complex [plasma membrane] (Homo sapiens)
SGCB:SGCD:SGCD,SGCZ:SGCA,SGCE [plasma membrane] (Homo sapiens)
SGCA, SGCE [plasma membrane] (Homo sapiens)
SGCA [plasma membrane] (Homo sapiens)
SGC:DAG1:SSPN complex [plasma membrane] (Homo sapiens)
SGCB:SGCD:SGCD,SGCZ:SGCA,SGCE [plasma membrane] (Homo sapiens)
SGCA, SGCE [plasma membrane] (Homo sapiens)
SGCA [plasma membrane] (Homo sapiens)
SGC:DAG1:SSPN complex translocates to plasma membrane (Homo sapiens)
SGC:DAG1:SSPN complex [plasma membrane] (Homo sapiens)
SGCB:SGCD:SGCD,SGCZ:SGCA,SGCE [plasma membrane] (Homo sapiens)
SGCA, SGCE [plasma membrane] (Homo sapiens)
SGCA [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16586 SGCA
Gene Names
SGCA, ADL, DAG2
Chain
signal peptide:1-23, chain:24-387
Reference Genes
BioGPS Gene:6442 SGCA
COSMIC - genes:SGCA SGCA
CTD Gene:6442 SGCA
dbSNP Gene:6442 SGCA
ENSEMBL:ENSG00000108823 SGCA
HGNC:10805 SGCA
KEGG:hsa:6442 SGCA
Monarch:6442 SGCA
NCBI Gene:6442 SGCA
OMIM:600119 SGCA
UCSC:Q16586 SGCA
Reference Transcript
RefSeq:NM_000023.4 SGCA
RefSeq:NM_001135697.3 SGCA
Other Identifiers
11731668_x_at
11732709_x_at
11751571_x_at
11761618_at
16835743
210632_3p_s_at
210632_PM_s_at
210632_s_at
3726255
3726256
3726258
3726259
3726260
3726261
3726262
3726263
3726264
3726265
3726266
3726267
3726268
3726270
3726271
3726272
3726273
3726274
38609_at
6442
8008277
A_23_P66637
GE79331
GO:0000139
GO:0003012
GO:0005509
GO:0005515
GO:0005737
GO:0005789
GO:0005856
GO:0005886
GO:0005911
GO:0006936
GO:0007517
GO:0016010
GO:0016011
GO:0016012
GO:0016020
GO:0042383
GO:0045121
GO:0048856
HMNXSV003051948
ILMN_1741007
L34355_at
PH_hs_0005586
TC17000657.hg
g557730_3p_a_at
p26027
Participates
as a member of
SGCA, SGCE [plasma membrane] (Homo sapiens)
Other forms of this molecule
SGCA [endoplasmic reticulum membrane]
SGCA [Golgi membrane]
Inferred To
Sgca [plasma membrane]
(Mus musculus)
Sgca [plasma membrane]
(Rattus norvegicus)
sgca [plasma membrane]
(Danio rerio)
sgca [plasma membrane]
(Xenopus tropicalis)
Scgalpha [plasma membrane]
(Drosophila melanogaster)
SGCA [plasma membrane]
(Bos taurus)
SGCA [plasma membrane]
(Canis familiaris)
SGCA [plasma membrane]
(Gallus gallus)
SGCA [plasma membrane]
(Sus scrofa)
sgca-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_000014.1
,
NP_001129169.1
ENSEMBL
ENST00000262018
,
ENSG00000108823
,
ENST00000344627
,
ENSP00000345522
,
ENSP00000262018
OpenTargets
ENSG00000108823
GeneCards
SGCA
HPA
ENSG00000108823-SGCA
PRO
Q16586
Pharos - Targets
Q16586
GlyGen
Q16586
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P50454 SERPINH1
1
SERPINH1 [endoplasmic reticulum lumen]
(R-HSA-2127480)
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 [plasma membrane]
(R-HSA-170842)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
0.556
3
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