NEIL3 recognizes and binds to 5-guanidinohydantoin

Stable Identifier
R-HSA-9629358
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NEIL3 recognizes and binds to 5-guanidinohydantoin
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NEIL3 recognizes and binds to oxidatively damaged guanine base in the form of 5-guanidinohydantoin (Gh), with a preference for single-strand DNA (ssDNA) over double-strand DNA (dsDNA) (Krokeide et al. 2013). NEIL3 also cleaves Gh in G4 quadruplex DNA formed by telomere sequences (Zhou et al. 2013).
Literature References
PubMed ID Title Journal Year
23755964 Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin

Krokeide, SZ, Laerdahl, JK, Salah, M, Luna, L, Cederkvist, FH, Fleming, AM, Burrows, CJ, Dalhus, B, Bjørås, M

DNA Repair (Amst.) 2013
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Authored
Orlic-Milacic, M  (2019-01-05)
Reviewed
Zhou, J  (2019-02-11)
Created
Orlic-Milacic, M  (2018-11-21)
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