Reactome | NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA

NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA

Stable Identifier

R-HSA-9629195

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SVG | | PPTX | SBGN

NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA

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NEIL3, a DNA glycosylase of the NEIL family, recognizes and binds to damaged telomeric DNA containing 5-guanidinohydantoin (Gh). Binding of NEIL3 to telomeric DNA is facilitated by interaction of NEIL3 with TRF1, a component of the telomeric shelterin complex (Zhou et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
28854357	NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis Zhou, J, Chan, J, Lambelé, M, Yusufzai, T, Stumpff, J, Opresko, PL, Thali, M, Wallace, SS	Cell Rep	2017