NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA

Stable Identifier
R-HSA-9629195
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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NEIL3, a DNA glycosylase of the NEIL family, recognizes and binds to damaged telomeric DNA containing 5-guanidinohydantoin (Gh). Binding of NEIL3 to telomeric DNA is facilitated by interaction of NEIL3 with TRF1, a component of the telomeric shelterin complex (Zhou et al. 2017).

Literature References
PubMed ID Title Journal Year
28854357 NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis

Zhou, J, Chan, J, Lambelé, M, Yusufzai, T, Stumpff, J, Opresko, PL, Thali, M, Wallace, SS

Cell Rep 2017
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