Reactome | XIAP binds CASP9

XIAP binds CASP9

Stable Identifier

R-HSA-9627078

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Apoptotic factor-mediated response (Homo sapiens)
      - Cytochrome c-mediated apoptotic response (Homo sapiens)
        
        Formation of apoptosome (Homo sapiens)
        
        Regulation of the apoptosome activity (Homo sapiens)
        
        XIAP binds CASP9 (Homo sapiens)

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X‑linked inhibitor‑of‑apoptosis protein (XIAP) associates with the cleaved form of CASP9. It does not influence pro‑caspase‑9 auto‑processing but inhibits the activity of processed caspase‑9 and then the activation of effector caspases within the apoptosome complex (Srinivasula SM et al. 2001; Bratton SB et al. 2001). BIR3 domain of XIAP binds IAP binding motif (IBM) at the amino terminus on the small subunit of CASP9, which becomes exposed after proteolytic processing of procaspase‑9 at Asp315 (Srinivasula SM et al. 2001). Furthermore, the C‑terminal extremity of BIR3 binds the dimer interface of CASP9, interfering with CASP9 dimerization and hiding the catalytic residue (Srinivasula SM et al. 2001, Shiozaki EN et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12620238	Mechanism of XIAP-mediated inhibition of caspase-9 Shiozaki, EN, Chai, J, Rigotti, DJ, Riedl, SJ, Li, P, Srinivasula, SM, Alnemri, ES, Fairman, R, Shi, Y	Mol. Cell	2003