Regulation of the apoptosome activity

Stable Identifier
R-HSA-9627069
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Regulation of the apoptosome activity
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Apoptosis is a controlled process of cell death, which must be tightly regulated to ensure that potentially dangerous cells are efficiently removed, while cells that are transiently stressed by environmental conditions can recover and survive (Bratton SB & Salvesen GS 2010). Defects in the regulation of apoptosis have been associated with the pathogenesis of disease states such as neurodegeneration and cancer (Favaloro B et al. 2012). The mitochondrial or intrinsic apoptotic pathway is regulated at multiple steps, including apoptosome formation and caspase‑9 activation.
Literature References
PubMed ID Title Journal Year
28192157 Apaf-1: Regulation and function in cell death

Kheirollahi, A, Shakeri, R, Davoodi, J

Biochimie 2017
20844150 Regulation of the Apaf-1-caspase-9 apoptosome

Bratton, SB, Salvesen, GS

J. Cell. Sci. 2010
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Orthologous Events
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Cross References
BioModels Database
Authored
Shamovsky, V  (2017-07-26)
Reviewed
Matthews, L  (2018-11-05)
Created
Shamovsky, V  (2018-11-01)
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