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DIABLO dimer [cytosol]
Stable Identifier
R-HSA-9627054
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
SMAC dimer, DIABLO:DIABLO
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Apoptotic factor-mediated response (Homo sapiens)
Cytochrome c-mediated apoptotic response (Homo sapiens)
Formation of apoptosome (Homo sapiens)
Regulation of the apoptosome activity (Homo sapiens)
XIAP binds CASP9 (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
Release of apoptotic factors from the mitochondria (Homo sapiens)
SMAC (DIABLO) forms dimer (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
SMAC, XIAP-regulated apoptotic response (Homo sapiens)
SMAC (DIABLO) binds to IAPs (Homo sapiens)
SMAC (DIABLO) binds XIAP (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
DIABLO dimer:XIAP [cytosol] (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
SMAC binds XIAP within apoptosome (Homo sapiens)
APAF1:CYCS:CASP9:XIAP:DIABLO [cytosol] (Homo sapiens)
DIABLO dimer:XIAP [cytosol] (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
SMAC binds XIAP:Caspase-3 (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
DIABLO:XIAP:Caspase-3 [cytosol] (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
SMAC binds XIAP:Caspase-7 (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
DIABLO:XIAP:Caspase-7 [cytosol] (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes (Homo sapiens)
Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 (Homo sapiens)
DIABLO dimer:XIAP [cytosol] (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
DIABLO:XIAP:Caspase-3 [cytosol] (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Homo sapiens)
DIABLO dimer:XIAP [cytosol] (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
DIABLO:XIAP:Caspase-7 [cytosol] (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
Dissociation of DIABLO:XIAP from the apoptosome complex (Homo sapiens)
APAF1:CYCS:CASP9:XIAP:DIABLO [cytosol] (Homo sapiens)
DIABLO dimer:XIAP [cytosol] (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
DIABLO dimer:XIAP [cytosol] (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
XIAP binds CASP3 (Homo sapiens)
DIABLO:XIAP:Caspase-3 [cytosol] (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
XIAP binds CASP7 (Homo sapiens)
DIABLO dimer [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
10972280
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
Chai, J
,
Wang, X
,
Shi, Y
,
Wu, JW
,
Du, C
,
Kyin, S
Nature
2000
Participants
components
x 2
DIABLO [cytosol]
(Homo sapiens)
Participates
as an input of
SMAC binds XIAP within apoptosome (Homo sapiens)
SMAC (DIABLO) binds XIAP (Homo sapiens)
SMAC binds XIAP:Caspase-7 (Homo sapiens)
SMAC binds XIAP:Caspase-3 (Homo sapiens)
as an output of
SMAC (DIABLO) forms dimer (Homo sapiens)
as a component of
DIABLO:XIAP:Caspase-7 [cytosol] (Homo sapiens)
DIABLO dimer:XIAP [cytosol] (Homo sapiens)
DIABLO:XIAP:Caspase-3 [cytosol] (Homo sapiens)
This entity regulates
Negatively
XIAP binds CASP7
(Homo sapiens)
XIAP binds CASP9
(Homo sapiens)
Inferred To
DIABLO dimer [cytosol]
(Bos taurus)
DIABLO dimer [cytosol]
(Canis familiaris)
DIABLO dimer [cytosol]
(Danio rerio)
DIABLO dimer [cytosol]
(Gallus gallus)
DIABLO dimer [cytosol]
(Mus musculus)
DIABLO dimer [cytosol]
(Rattus norvegicus)
DIABLO dimer [cytosol]
(Sus scrofa)
DIABLO dimer [cytosol]
(Xenopus tropicalis)
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