E2-mediated FOS gene expression

Stable Identifier
R-HSA-9625465
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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E2-mediated FOS gene expression
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The FOS gene encodes FOS, a leucine zipper protein that dimerizes with other FOS, JUN or ATF family members to form the ubiquitous transcription factor complex AP-1 (reviewed in Milde-Langosch, 2005; Hess et al, 2004). AP-1 transcription factors regulate gene expression in response to numerous upstream stimuli, including growth factors, hormones and cytokines and influence proliferation, differentiation and apoptosis, among other processes (reviewed in Shaulina et al, 2002; Thiel and Rossler, 2017).
Transcription of the FOS gene is regulated in part by binding of TCF (a complex of SRF and phosphorylated ELK1) to the serum response element (SRE) in the promoter (Marais et al, 1993; Gille et al, 1995; Duan et al, 2001; reviewed in Treisman, 1995)
Literature References
PubMed ID Title Journal Year
16199154 The Fos family of transcription factors and their role in tumourigenesis

Milde-Langosch, K

Eur. J. Cancer 2005
15564374 AP-1 subunits: quarrel and harmony among siblings

Hess, J, Angel, P, Schorpp-Kistner, M

J Cell Sci 2004
8386592 The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

Marais, R, Wynne, J, Treisman, R

Cell 1993
28012964 Resveratrol regulates gene transcription via activation of stimulus-responsive transcription factors

Thiel, G, Rössler, OG

Pharmacol. Res. 2017
7588619 Journey to the surface of the cell: Fos regulation and the SRE

Treisman, R

EMBO J. 1995
11145955 Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1

Duan, R, Xie, W, Burghardt, RC, Safe, S

J. Biol. Chem. 2001
11988758 AP-1 as a regulator of cell life and death

Shaulian, E, Karin, M

Nat. Cell Biol. 2002
7889942 ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

Gille, H, Kortenjann, M, Thomae, O, Moomaw, C, Slaughter, C, Cobb, MH, Shaw, PE

EMBO J 1995
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOS gene:SRF:p-4S,T336 ELK1 [nucleoplasm] (Homo sapiens)
Active Unit
p-4S, T336 ELK1:SRF [nucleoplasm]
Regulator
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Homo sapiens)
Active Unit
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane]
Authored
Rothfels, K  (2018-12-15)
Reviewed
Levin, ER  (2019-02-20)
Created
Rothfels, K  (2018-10-19)
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