The FOS gene encodes FOS, a leucine zipper protein that dimerizes with other FOS, JUN or ATF family members to form the ubiquitous transcription factor complex AP-1 (reviewed in Milde-Langosch, 2005; Hess et al, 2004). AP-1 transcription factors regulate gene expression in response to numerous upstream stimuli, including growth factors, hormones and cytokines and influence proliferation, differentiation and apoptosis, among other processes (reviewed in Shaulina et al, 2002; Thiel and Rossler, 2017).Transcription of the FOS gene is regulated in part by binding of TCF (a complex of SRF and phosphorylated ELK1) to the serum response element (SRE) in the promoter (Marais et al, 1993; Gille et al, 1995; Duan et al, 2001; reviewed in Treisman, 1995)
Milde-Langosch, K
Angel, P, Schorpp-Kistner, M, Hess, J
Treisman, R, Wynne, J, Marais, R
Rössler, OG, Thiel, G
Treisman, R
Xie, W, Safe, S, Duan, R, Burghardt, RC
Shaulian, E, Karin, M
Moomaw, C, Gille, H, Shaw, PE, Cobb, MH, Thomae, O, Slaughter, C, Kortenjann, M
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