MPZ is the most abundant component of the myelin sheath that surrounds axons of the peripheral nervous system. Expression of MPZ is dependent on axonal signals that stimulate the binding of transcriptional regulators EGR2 and SOX10 to response elements in intron 1, where they recruit SMARCA4 to the gene (Le Blanc et al, 2006; Le Blanc et al, 2007; Jones et al, 2007; Marathe et al, 2013). SOX10 additionally binds to elements in the promoter of MPZ, where it regulates both basal and upregulated MPZ expression (Peirano et al, 2000).
Goerich, DE, Wegner, M, Riethmacher, D, Peirano, RI
Yeung, KC, Datar, I, Zhang, X, Mehta, G, Marathe, HG, Mehrotra, A, de la Serna, IL
Nagarajan, R, Jones, EA, Mager, GM, Ward, RM, Chang, LW, Svaren, J, Jang, SW, Srinivasan, R, Gokey, NG
Ward, RM, Svaren, J, Leblanc, SE
Wrabetz, L, Ward, RM, Svaren, J, Jang, SW, Leblanc, SE
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