MPZ gene expression

Stable Identifier
R-HSA-9614787
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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MPZ gene expression
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MPZ is the most abundant component of the myelin sheath that surrounds axons of the peripheral nervous system. Expression of MPZ is dependent on axonal signals that stimulate the binding of transcriptional regulators EGR2 and SOX10 to response elements in intron 1, where they recruit SMARCA4 to the gene (Le Blanc et al, 2006; Le Blanc et al, 2007; Jones et al, 2007; Marathe et al, 2013). SOX10 additionally binds to elements in the promoter of MPZ, where it regulates both basal and upregulated MPZ expression (Peirano et al, 2000).
Literature References
PubMed ID Title Journal Year
10757804 Protein zero gene expression is regulated by the glial transcription factor Sox10

Peirano, RI, Goerich, DE, Riethmacher, D, Wegner, M

Mol. Cell. Biol. 2000
23874858 SWI/SNF enzymes promote SOX10- mediated activation of myelin gene expression

Marathe, HG, Mehta, G, Zhang, X, Datar, I, Mehrotra, A, Yeung, KC, de la Serna, IL

PLoS ONE 2013
18634568 Interactions of Sox10 and Egr2 in myelin gene regulation

Jones, EA, Jang, SW, Mager, GM, Chang, LW, Srinivasan, R, Gokey, NG, Ward, RM, Nagarajan, R, Svaren, J

Neuron Glia Biol. 2007
17325040 Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10

Leblanc, SE, Ward, RM, Svaren, J

Mol. Cell. Biol. 2007
16373334 Direct regulation of myelin protein zero expression by the Egr2 transactivator

Leblanc, SE, Jang, SW, Ward, RM, Wrabetz, L, Svaren, J

J. Biol. Chem. 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MPZ gene:EGR2:SOX10:SMARCA4 [nucleoplasm] (Homo sapiens)
Active Unit
EGR2 [nucleoplasm]
SMARCA4 [nucleoplasm]
SOX10 [nucleoplasm]
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-07-28)
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