Sox10 and Hdac2 interact to regulate expression of genes involved in peripheral myelination

Stable Identifier
R-RNO-9614293
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sox10 and Hdac2 interact to regulate expression of genes involved in peripheral myelination
Hdac2 and Sox10 co-immunoprecipitate from primary rat Schwann cells, and by ChIP are associated with the promoters and enhancer elements of key regulators of myelination in the peripheral nervous system such as Krox20/Egr2 and Sox10, as well as at transcriptional targets of this program like myelin protein zero (Mpz/P0). Double knockout of Hdac2 and Hdac1 (which has partially overlapping function and can compensate for loss of Hdac2) decreases expression of Sox10, Egr2, but increases expression of Pou3f1. This latter observation is likely a secondary consequence of decreased Egr2 expression, as Pou3f1 expression is subject to Egr2-dependent downregulation at the promyelination stage (Jacob et al, 2011).
Literature References
PubMed ID Title Journal Year
21423190 HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells

Jacob, C, Christen, CN, Pereira, JA, Somandin, C, Baggiolini, A, Lötscher, P, Ozçelik, M, Tricaud, N, Meijer, D, Yamaguchi, T, Matthias, P, Suter, U

Nat. Neurosci. 2011
Participants
Input
Output
Orthologous Events
SOX10 dimer binds the POU3F1 promoter (Homo sapiens)
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-07-24)
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