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TRAF2, TRAF6 [cytosol]
Stable Identifier
R-HSA-918188
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
Phosphorylation and release of IRF7 (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Phosphorylation of TBK1/IKBKE (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xTBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Recruitment of IRF7 to TRAF6 (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Recruitment of TANK to TRAF6 (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Recruitment of TRAF6/TRAF2 to MAVS (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
TBK1, IKBKE form homodimers (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xTBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
Activation of IKK by MEKK1 (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Interaction of MEKK1 with TRAF6 (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP4 deubiquitinate TRAF2,TRAF6 (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Participants
members
TRAF2 [cytosol]
(Homo sapiens)
TRAF6 [cytosol]
(Homo sapiens)
Participates
as an output of
USP4 deubiquitinate TRAF2,TRAF6 (Homo sapiens)
as an input of
Recruitment of TRAF6/TRAF2 to MAVS (Homo sapiens)
as a component of
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
Inferred To
TRAF2, TRAF6 [cytosol]
(Bos taurus)
TRAF2, TRAF6 [cytosol]
(Canis familiaris)
TRAF2, TRAF6 [cytosol]
(Gallus gallus)
TRAF2, TRAF6 [cytosol]
(Mus musculus)
TRAF2, TRAF6 [cytosol]
(Rattus norvegicus)
TRAF2, TRAF6 [cytosol]
(Sus scrofa)
TRAF2, TRAF6 [cytosol]
(Xenopus tropicalis)
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