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TRAF2, TRAF6
Stable Identifier
R-HSA-918188
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
Phosphorylation and release of IRF7 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF7 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Recruitment of IRF7 to TRAF6 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF7 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Recruitment of TANK to TRAF6 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Recruitment of TRAF6/TRAF2 to IPS-1 (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
Activation of IKK by MEKK1 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Interaction of MEKK1 with TRAF6 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP4 deubiquitinate TRAF2,TRAF6 (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
Participants
members
TRAF2 [cytosol] (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Participant Of
input
Recruitment of TRAF6/TRAF2 to IPS-1
hasComponent
IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane]
output
USP4 deubiquitinate TRAF2,TRAF6
Inferred To
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Caenorhabditis elegans)
TRAF2, TRAF6 [cytosol] (Bos taurus)
TRAF2, TRAF6 [cytosol] (Canis familiaris)
TRAF2, TRAF6 [cytosol] (Danio rerio)
TRAF2, TRAF6 [cytosol] (Gallus gallus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
TRAF2, TRAF6 [cytosol] (Rattus norvegicus)
TRAF2, TRAF6 [cytosol] (Sus scrofa)
TRAF2, TRAF6 [cytosol] (Taeniopygia guttata)
TRAF2, TRAF6 [cytosol] (Xenopus tropicalis)
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