Reactome | TRAF6/or TRAF2 interacts with IPS-1

TRAF6/or TRAF2 interacts with IPS-1

Stable Identifier

R-GGA-1227775

Type

Reaction [binding]

Species

Gallus gallus

Related Species

Infectious bronchitis virus

Compartment

mitochondrial outer membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In mammals, the response to viral infection is mediated through direct and specific interaction between a TRAF-interaction motif (TIM) of IPS-1 and TRAFs, which can recruit other molecules into signaling complex [Ye H et al 2002, Xu LG et al 2005, Saha SK et al 2006, Konno H et al 2009]. IPS-1 harbors few distinct TIMs. One of the motifs is located at aa 143-PVQET-147 and binds both TRAF2 and TRAF3, while TRAF6 exclusively binds to aa 153-PGENSE-158 & 455-PEENEY-460 motifs. IPS-1 mediated response to viral infection in mammals requires:

TRAF6 to activate NFkB, MAPK and IRF7, but not IRF3.[Xu LG et al 2005, Yoshida R et al 2009, Konno H et al 2009].
TRAF3 to activate IRF3 and IRF7 [Saha SK et al 2006, Oganesyan G et al 2006].
TRAF2 to activate p38 MAPK and contribute to NFkB induction [Mikkelsen SS et al 2009, Xu LG et al 2005].

Predicted chicken TRAF2, TRAF3 and TRAF6 proteins show 75, 82 and 73% amino acid sequence identity to their human counterparts respectively. In this project we assume that chicken TRAF proteins function similar to mammalian TRAFs upon viral infection.

Literature References

PubMed ID	Title	Journal	Year
16153868	VISA is an adapter protein required for virus-triggered IFN-beta signaling Xu, LG, Wang, YY, Han, KJ, Li, LY, Zhai, Z, Shu, HB	Mol Cell	2005
19479062	TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA Konno, H, Yamamoto, T, Yamazaki, K, Gohda, J, Akiyama, T, Semba, K, Goto, H, Kato, A, Yujiri, T, Imai, T, Kawaguchi, Y, Su, B, Takeuchi, O, Akira, S, Tsunetsugu-Yokota, Y, Inoue, J	PLoS One	2009
18984593	TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway Yoshida, R, Takaesu, G, Yoshida, H, Okamoto, F, Yoshioka, T, Choi, Y, Akira, S, Kawai, T, Yoshimura, A, Kobayashi, T	J Biol Chem	2008
19224920	RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1 Mikkelsen, SS, Jensen, SB, Chiliveru, S, Melchjorsen, J, Julkunen, I, Gaestel, M, Arthur, JS, Flavell, RA, Ghosh, S, Paludan, SR	J Biol Chem	2009