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USP18 [cytosol]
Stable Identifier
R-HSA-912325
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UBP43, Ubl carboxyl-terminal hydrolase 18, UBP18_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Regulation of IFNA/IFNB signaling (Homo sapiens)
UBP43 binds IFNAR2 and prevents JAK1 interaction (Homo sapiens)
IFNAR2c:UBP43 [plasma membrane] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP18 binds IKBKG within IKK complex (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP18 binds IKBKG within IKK complex (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP18 binds IKBKG within IKK complex (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP18 binds IKBKG within IKK complex (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP18 binds IKBKG within IKK complex (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP18 binds IKBKG within IKK complex (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP18 binds IKBKG within IKK complex (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP18 binds IKBKG within IKK complex (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP18 binds IKBKG within IKK complex (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP18 binds IKBKG within IKK complex (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP18 deubiquitinates TAK1:TAB1 (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18:MAP3K7:TAB1 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
USP18:PolyUb-MAP3K7:TAB1 [cytosol] (Homo sapiens)
USP18 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UMW8 USP18
Gene Names
USP18, ISG43
Chain
chain:1-372
Reference Genes
BioGPS Gene:11274 USP18
COSMIC (genes):USP18 USP18
CTD Gene:11274 USP18
dbSNP Gene:11274 USP18
ENSEMBL:ENSG00000184979 USP18
HGNC:12616 USP18
KEGG:hsa:11274 USP18
Monarch:11274 USP18
NCBI Gene:11274 USP18
OMIM:607057 USP18
UCSC:Q9UMW8 USP18
Reference Transcript
RefSeq:NM_017414.3 USP18
Other Identifiers
11274
11721349_s_at
16926942
219211_PM_at
219211_at
3936551
3936552
3936553
3936554
3936555
3936556
3936557
3936558
3936559
3936560
3936562
3936563
3936564
3936565
3936566
3936567
3936568
3936569
3936570
3936571
3936572
3936573
3936577
3936579
3936677
3937491
3938047
3952055
3952056
3953218
3953219
3953220
3953237
3953238
3953239
3953240
3953241
3953244
3953246
3953247
3953514
3953955
51972_at
8071155
8074606
A_23_P132159
A_32_P132206
GE469920
GE55273
GO:0002376
GO:0003824
GO:0004843
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006508
GO:0008234
GO:0009617
GO:0016579
GO:0016787
GO:0019785
GO:0035634
GO:0043226
GO:0043231
GO:0050727
GO:0060090
GO:0060339
GO:0098542
GO:0140096
GO:0140374
HMNXSV003016543
HMNXSV003034903
ILMN_1740200
PH_hs_0027633
TC22000029.hg
g8394518_3p_at
Participates
as a component of
USP18:MAP3K7:TAB1 [cytosol] (Homo sapiens)
USP18:PolyUb-MAP3K7:TAB1 [cytosol] (Homo sapiens)
IFNAR2c:UBP43 [plasma membrane] (Homo sapiens)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
as an input of
UBP43 binds IFNAR2 and prevents JAK1 interaction (Homo sapiens)
USP18 binds IKBKG within IKK complex (Homo sapiens)
Inferred To
Usp18 [cytosol]
(Mus musculus)
Usp18 [cytosol]
(Rattus norvegicus)
USP18 [cytosol]
(Bos taurus)
USP18 [cytosol]
(Canis familiaris)
USP18 [cytosol]
(Drosophila melanogaster)
USP18 [cytosol]
(Gallus gallus)
USP18 [cytosol]
(Sus scrofa)
usp-48 [cytosol]
(Caenorhabditis elegans)
usp18 [cytosol]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSG00000184979
,
ENST00000215794
,
ENSP00000215794
OpenTargets
ENSG00000184979
GeneCards
USP18
HPA
ENSG00000184979-USP18
ZINC - Substances
UBP18_HUMAN
ZINC target
Q9UMW8
PRO
Q9UMW8
Pharos - Targets
Q9UMW8
Orphanet
USP18
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05161 ISG15
4
ISG15 [cytosol]
(R-HSA-936552)
K168-PCNA-G157-ISG15 [nucleoplasm]
(R-HSA-5653744)
K164-PCNA-G157-ISG15 [nucleoplasm]
(R-HSA-5653745)
ISG15 [nucleoplasm]
(R-HSA-5653665)
0.873
9
UniProt:USP41 UBP41
0.564
2
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
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