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Usp18 [cytosol]
Stable Identifier
R-RNO-912325
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
USP18, Q6AYC7
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Antimicrobial mechanism of IFN-stimulated genes (Rattus norvegicus)
ISG15 antiviral mechanism (Rattus norvegicus)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Interferon alpha/beta signaling (Rattus norvegicus)
Regulation of IFNA/IFNB signaling (Rattus norvegicus)
UBP43 binds IFNAR2 and prevents JAK1 interaction (Rattus norvegicus)
IFNAR2c:UBP43 [plasma membrane] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Ub-specific processing proteases (Rattus norvegicus)
USP18 deubiquitinates TAK1:TAB1 (Rattus norvegicus)
USP18:MAP3K7:TAB1 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
USP18:PolyUb-MAP3K7:TAB1 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
Usp18 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q6AYC7
Gene Names
Usp18
Reference Genes
BioGPS Gene:312688 Usp18
ENSEMBL:ENSRNOG00000037198
KEGG:rno:312688 Usp18
Monarch:312688 Usp18
NCBI Gene:312688 Usp18
UCSC:Q6AYC7 Usp18
Reference Transcript
RefSeq:NM_001014058.2 Usp18
Other Identifiers
10858370
1389034_at
17786684
17796641
312688
5736834
5753491
5788805
5810952
5842657
6075039
6097405
6117161
6149332
6246155
6294076
6377570
6408018
6453086
6492654
A_44_P157229
A_44_P284200
A_64_P157059
GE1210278
GE19223
GO:0004843
GO:0009617
GO:0016579
GO:0019785
GO:0035634
ILMN_1349649
PH_rn_0008932
rc_AA851237_at
Participates
as a component of
USP18:MAP3K7:TAB1 [cytosol] (Rattus norvegicus)
USP18:PolyUb-MAP3K7:TAB1 [cytosol] (Rattus norvegicus)
IFNAR2c:UBP43 [plasma membrane] (Rattus norvegicus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Rattus norvegicus)
as an input of
UBP43 binds IFNAR2 and prevents JAK1 interaction (Rattus norvegicus)
USP18 binds IKBKG within IKK complex (Rattus norvegicus)
Inferred From
USP18 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001014080.1
ENSEMBL
ENSRNOP00000053020
,
ENSRNOT00000056174
,
ENSRNOG00000037198
RGD
1359153
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