beta-alanine + pyruvate => 3-oxopropanoate + alanine

Stable Identifier
R-HSA-909776
Type
Reaction
Species
Homo sapiens
Compartment
mitochondrial matrix
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beta-alanine + pyruvate => 3-oxopropanoate + alanine
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Mitochondrial AGXT2 tetramer catalyzes the reaction of beta-alanine and pyruvate to form 3-oxopropanoate and alanine. While the human mitochondrial AGXT2 enzyme has been characterized experimentally in other respects (Rodionov et al. 2010), its ability to catalyze this transamination reaction is inferred from the properties of its rat homologue.

Literature References
PubMed ID Title Journal Year
20018850 Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production

Lentz, SR, Rodionov, RN, Stevens, JW, Murry, DJ, Vaulman, SF

J Biol Chem 2010
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Catalyst Activity

beta-alanine-pyruvate transaminase activity of AGXT2 tetramer [mitochondrial matrix]

Physical Entity
AGXT2 tetramer [mitochondrial matrix] (Homo sapiens)
Activity
beta-alanine-pyruvate transaminase activity (GO:0016223)
Inferred From
beta-alanine + pyruvate => 3-oxopropanoate + alanine (Rattus norvegicus)
Cross References
Rhea
Authored
D'Eustachio, P  (2010-07-07)
Reviewed
Jassal, B  (2010-11-09)
Created
D'Eustachio, P  (2010-07-07)
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