Erythropoietin activates Phospholipase C gamma (PLCG)

Stable Identifier
R-HSA-9027277
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Erythropoietin activates Phospholipase C gamma (PLCG)
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PLCG1 (Phospholipase C gamma1) or PLCG2 bound to the activated EPOR is phosphorylated on tyrosine residues by the kinase LYN (Ren et al. 1994, and inferred from mouse homologs). PLCG1 and PLCG2 produce inositol 1,4,5-trisphosphate which then activates calcium signaling, and diacylglycerol (DAG) which then activates protein kinase C (PKC).

Literature References
PubMed ID Title Journal Year
8034732 Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line

Ren, HY, Shimizu, R, Miura, Y, Okada, K, Komatsu, N

J. Biol. Chem. 1994
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activation of phospholipase C activity (0007202)
Cross References
BioModels Database
Authored
May, B  (2017-10-29)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-10-29)
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