EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma

Stable Identifier
R-HSA-9027373
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PLCG2 (PLCgamma2) binds phosphotyrosine-432 and phosphotyrosine-480 of EPOR (Montoye et al. 2005, and inferred from moue homologs). PLCG1 can also bind the phosphorylated EPOR (inferred from mouse homologs). After binding, PLCG2 is phosphorylated (Ren et al. 1994)
Literature References
PubMed ID Title Journal Year
8034732 Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line

Ren, HY, Komatsu, N, Shimizu, R, Okada, K, Miura, Y

J. Biol. Chem. 1994
15644415 A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach

Montoye, T, Lemmens, I, Catteeuw, D, Eyckerman, S, Tavernier, J

Blood 2005
Participants
Input
Output
Participates
as an event of
Inferred From
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Plcg1,2 (Mus musculus)
Authored
May, B  (2017-10-30)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-11-01)
Cite Us!