LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2

Stable Identifier
R-HSA-9027425
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PLCG1 (Phospholipase C gamma1) or PLCG2 bound to the activated EPOR is phosphorylated on tyrosine residues by the kinase LYN (Ren et al. 1994, and inferred from mouse homologs).

Literature References
PubMed ID Title Journal Year
8034732 Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line

Ren, HY, Komatsu, N, Shimizu, R, Okada, K, Miura, Y

J. Biol. Chem. 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PLCG1,2 [plasma membrane]
Physical Entity
Activity
Inferred From
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