ESR1:ESTG binds to proximal and distal regions of the CTSD promoter

Stable Identifier
Reaction [binding]
Homo sapiens
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Cathepsin D (CTSD) is an estrogen-responsive gene encoding a lysosomal protease with roles in cellular proliferation, apoptosis, cell migration and differentiation, among others (reviewed in Zaidi et al, 2008; Khalkhali-Ellis and Hendrix, 2015). Estrogen-dependence is conferred by the presence of non-canonical EREs in the proximal and distal promoter regions which are bound by ESR1 in a ligand-dependent manner (Augereau et al, 1994; Cavaillès et al, 1993; Wang et al, 1997; Wang et al, 1998; Xing and Archer, 1998; Shang et al, 2000; Wang et al, 2001; Bourdeau et al, 2004). Estrogen-stimulated transcriptional activation is facilitated by the formation of ESR1-dependent loops and by the cyclic recruitment of activators, coactivators, HATs and other components of the general transcriptional machinery (Shang et al, 2000; Bretschneider et al, 2008).

Literature References
PubMed ID Title Journal Year
9731700 Upstream stimulatory factors mediate estrogen receptor activation of the cathepsin D promoter

Archer, TK, Xing, W

Mol. Endocrinol. 1998
9611253 Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes

Safe, S, Hoivik, D, Pollenz, R, Wang, F

Nucleic Acids Res. 1998
11136970 Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

Hu, X, Brown, M, DiRenzo, J, Shang, Y, Lazar, MA

Cell 2000
25663755 Two Faces of Cathepsin D: Physiological Guardian Angel and Pathological Demon

Khalkhali-Ellis, Z, Hendrix, MJ

Biol Med (Aligarh) 2014
18762174 Cathepsin D: a cellular roadmap

Kalbacher, H, Zaidi, N, Nieke, S, Maurer, A

Biochem. Biophys. Res. Commun. 2008
7935485 Characterization of the proximal estrogen-responsive element of human cathepsin D gene

Miralles, F, Gaudelet, C, Augereau, P, Rochefort, H, Cavaillès, V, Parker, M

Mol. Endocrinol. 1994
15001666 Genome-wide identification of high-affinity estrogen response elements in human and mouse

Deschênes, J, Métivier, R, Nguyen, D, Bretschneider, N, Nagai, Y, Gannon, F, White, JH, Bourdeau, V, Mader, S

Mol. Endocrinol. 2004
19383337 E2-mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements

Reid, G, Kangaspeska, S, Bretschneider, N, Seifert, M, Gannon, F, Denger, S

Mol Oncol 2008
9201922 Identification of a functional imperfect estrogen-responsive element in the 5'-promoter region of the human cathepsin D gene

Archer, TK, Safe, S, Xing, W, Porter, W, Wang, F

Biochemistry 1997
8419924 Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells

Augereau, P, Rochefort, H, Cavaillès, V

Proc. Natl. Acad. Sci. U.S.A. 1993
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