MECP2 regulates transcription of neuronal ligands

Stable Identifier
R-HSA-9022702
Type
Pathway
Species
Homo sapiens
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MECP2 regulates transcription of neuronal ligands
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Ligands regulated by MECP2 include BDNF (reviewed by Li and Pozzo Miller 2014, and KhorshidAhmad et al. 2016), CRH (McGill et al. 2006, Samaco et al. 2012), SST (Somatostatin) (Chahrour et al. 2008), and DLL1 (Li et al. 2014).

Literature References
PubMed ID Title Journal Year
17108082 Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome

McGill, BE, Bundle, SF, Yaylaoglu, MB, Carson, JP, Thaller, C, Zoghbi, HY

Proc. Natl. Acad. Sci. U.S.A. 2006
22231481 Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome

Samaco, RC, Mandel-Brehm, C, McGraw, CM, Shaw, CA, McGill, BE, Zoghbi, HY

Nat. Genet. 2012
25420914 Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway

Li, H, Zhong, X, Chau, KF, Santistevan, NJ, Guo, W, Kong, G, Li, X, Kadakia, M, Masliah, J, Chi, J, Jin, P, Zhang, J, Zhao, X, Chang, Q

Nat Commun 2014
18511691 MeCP2, a key contributor to neurological disease, activates and represses transcription

Chahrour, M, Jung, SY, Shaw, C, Zhou, X, Wong, ST, Qin, J, Zoghbi, HY

Science 2008
25579386 Transcriptional Regulation of Brain-Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS)

KhorshidAhmad, T, Acosta, C, Cortes, C, Lakowski, TM, Gangadaran, S, Namaka, M

Mol. Neurobiol. 2016
23597512 BDNF deregulation in Rett syndrome

Li, W, Pozzo-Miller, L

Neuropharmacology 2014
Participants
Events
Participant Of
hasEvent
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-25)