MECP2:SIN3A complex binds the promoter of the BDNF gene

Stable Identifier
R-HSA-9006050
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MECP2:SIN3A complex binds the promoter of the BDNF gene
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Based on studies in mice, the complex of MECP2, SIN3A and HDAC1 binds one of several alternative promoters of the brain-derived neurotrophic factor (BDNF) gene, the promoter in front of the BDNF exon IV (Martinowich et al. 2003). This promoter is homologous to the promoter in front of the rat Bdnf exon III, which was also shown to be occupied by Mecp2 (Chen et al. 2003).
Literature References
PubMed ID Title Journal Year
14593183 Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2

Chen, WG, Chang, Q, Lin, Y, Meissner, A, West, AE, Griffith, EC, Jaenisch, R, Greenberg, ME

Science 2003
14593184 DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation

Martinowich, K, Hattori, D, Wu, H, Fouse, S, He, F, Hu, Y, Fan, G, Sun, YE

Science 2003
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Mecp2:Sin3a complex binds the Bdnf gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-05-12)
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